Document Detail

Studies of the renal excretion of the hydroxyl analogue of methionine by the chick.
MedLine Citation:
PMID:  3748950     Owner:  NLM     Status:  MEDLINE    
Athens-Canadian Random Bred adult cockerels and chicks were used to compare the metabolism of the free acid form of the methionine hydroxyl analogue (HMB-FA) to L-methionine (LMET). The first experiment was to determine whether HMB-FA was excreted by the kidneys, thus reducing the amount available for protein synthesis. Fasted adult male chickens were given a single oral dose of HMB-FA or LMET containing a radioactive tracer. Urine was collected and analyzed for the amount of radioactive tracer present; blood samples were subjected to blood gas analyses to assess the physiological status of the bird. It was concluded that LMET was the major methionine analogue excreted from roosters dosed with either HMB-FA or LMET, and that HMB-FA was not excreted by the avian kidney. The second experiment was to determine whether the acid-base status of the diet influences the utilization of HMB-FA. Two levels of dietary LMET or HMB-FA and six levels of dietary base were fed to chicks in a complete 2 X 2 X 6 factorial design for a period of 20 days, after which weight gain and feed consumption were determined. The results indicated that the acid-base status of the diet can play a role in maximizing the gain of chicks fed HMB-FA. Optimal dietary conditions for comparing the efficacy of HMB-FA with LMET and the poor performance of HMB-FA in crystalline amino acid diets are discussed.
J M Saroka; G F Combs
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Poultry science     Volume:  65     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-10-20     Completed Date:  1986-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1375-82     Citation Subset:  IM    
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MeSH Terms
Acid-Base Equilibrium
Chickens / metabolism*
Kidney / metabolism*
Methionine / analogs & derivatives*,  metabolism*,  urine
Reg. No./Substance:
583-91-5/alpha-hydroxy-gamma-methylmercaptobutyric acid; 63-68-3/Methionine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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