Document Detail


Studies on the purification and characterization of human urinary plasminogen and plasmin.
MedLine Citation:
PMID:  6445089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new method is described for the preparation of highly purified human plasminogen and plasmin with specific activity of 32 CTA units per mg of protein. With this method, the purification of the urinary plasminogen + plasmin antigenic materials from patients with chronic glomerulonephritis, disseminated intravascular coagulation syndrome and severe toxemia of pregnancy was performed, and the resulting highly purified proenzyme and enzyme were analyzed by immunoelectrophoresis, separative agar electrophoresis, gel filtration and SDS-gel electrophoresis. Our findings indicated that urinary plasmin reflects more closely the extent of intraglomerular fibrinolysis, while urinary plasminogen reflects non-selective proteinuria in patients with chronic glomerulonephritis or severe toxemia of pregnancy.
Authors:
H F Chen; M Nakabayashi; K Satoh; S Sakamoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  42     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-06-16     Completed Date:  1980-06-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1536-47     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatography, Gel
Chronic Disease
Disseminated Intravascular Coagulation / urine
Electrophoresis, Agar Gel
Electrophoresis, Polyacrylamide Gel
Female
Fibrinolysin / isolation & purification*,  urine
Glomerulonephritis / urine
Humans
Immunoelectrophoresis
Molecular Weight
Plasminogen / isolation & purification*,  urine
Pre-Eclampsia / urine
Pregnancy
Rabbits
Chemical
Reg. No./Substance:
9001-91-6/Plasminogen; EC 3.4.21.7/Fibrinolysin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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