Document Detail

Studies on the prostate glands of adult inbred LSH hamsters.
MedLine Citation:
PMID:  1153428     Owner:  NLM     Status:  MEDLINE    
We have studied several parameters of prostate function in two inbred lines (2.4 and SsLak) of young and old LSH hamsters. These included weight, acid phosphatase, and [3H]testosterone uptake as influenced by age, castration, and androgen treatment. In the hamster, prostatic acid phosphatase concentration was found to vary inversely with androgen levels, contrary to the usual assumption that this enzyme is androgen dependent. Prostatic uptake of tritiated testosterone was enhanced by castration and by treatment of castrates with doses of androgen which induced a moderate increase in gland size. With advancing age, the prostates of LSH hamsters (both strains) became atrophic rather than hyperplastic, in contrast with a previous report (1). This atrophy appeared to be a consequence of decreased testicular function. The LSH hamsters appear to be a suitable model for the study of senescent changes in the male reproductive system.
M Butler; W K Sawyer; T Giannina; B G Steinetz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)     Volume:  149     ISSN:  0037-9727     ISO Abbreviation:  Proc. Soc. Exp. Biol. Med.     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-10-21     Completed Date:  1975-10-21     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  7505892     Medline TA:  Proc Soc Exp Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  506-10     Citation Subset:  IM    
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MeSH Terms
Acid Phosphatase / analysis*
Age Factors
Organ Size
Prostate / drug effects,  physiology*
Seminal Vesicles
Testosterone / metabolism*,  pharmacology
Reg. No./Substance:
10028-17-8/Tritium; 58-22-0/Testosterone; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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