| Studies of the proliferation and differentiation of immature myeloid cells in vitro. II. Acute myelogenous leukemia. | |
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MedLine Citation:
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PMID: 2643858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immature myeloid cells prepared from patients with AML were placed into suspension culture and studied over a 2-week period. Cell numbers usually fell and viability was not well maintained. Some degree of differentiation was observed in most cultures. Considering these observations, together with those derived from parallel studies of immature CML cells, the data suggest that AML cells are more dependent than CML cells on environmental conditions for the maintenance of cell viability and proliferation. This is especially the case for AML cells obtained at the time of initial diagnosis. On the other hand, AML cells and myeloid blastic crisis CML cells are similar with respect to their apparent greater ability to differentiate in vitro than in vivo. The addition of recombinant hemopoietins to the suspension cultures of AML cells is associated with either increased proliferation or differentiation but not both. The cells of different patients respond differently to the different hemopoietins and the different hemopoietins produce different affects in cultures of cells obtained from the same patient. |
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Authors:
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Z Wang; X Z Gao; H D Preisler |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of hematology Volume: 30 ISSN: 0361-8609 ISO Abbreviation: Am. J. Hematol. Publication Date: 1989 Feb |
Date Detail:
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Created Date: 1989-02-28 Completed Date: 1989-02-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 82-5 Citation Subset: IM |
Affiliation:
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Roswell Park Memorial Institute, Department of Hematologic Oncology, Buffalo, NY 14263. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Cells
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metabolism,
pathology* Bone Marrow / metabolism, pathology* Cell Differentiation / drug effects Cell Division / drug effects Cell Survival Cells, Cultured Colony-Stimulating Factors / pharmacology DNA / biosynthesis Granulocyte-Macrophage Colony-Stimulating Factor Growth Substances / pharmacology Humans Interleukin-1 / pharmacology Leukemia, Myeloid, Acute / metabolism, pathology* |
| Grant Support | |
ID/Acronym/Agency:
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CA 1285/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Colony-Stimulating Factors; 0/Growth Substances; 0/Interleukin-1; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor; 9007-49-2/DNA |
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