| Studies on preventive effects of diphenyl diselenide on acetaminophen-induced hepatotoxicity in rats. | |
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MedLine Citation:
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PMID: 19162454 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Organoselenium are compounds with important antioxidant activity and with many biological activities interesting from pharmacological point of view. The aim of this study was to evaluate the protective effect of diphenyl diselenide (PhSe)(2) on hepatotoxicity caused by administration of acetaminophen (AA) in rats. Rats received (PhSe)(2) orally (31mg/kg, dissolved in canola oil) for 2 days. After the second day of treatment, rats received AA orally (2g/kg) in unique dose. Twenty-four hours after the last administration of AA, plasma was used for biochemical assays aspartate (AST) and alanine aminotransferases (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), gamma-glutamyl transferase (gamma-GT) activities. Glutathione-S-transferase (GST), delta-aminolevulinic dehydratase (delta-ALA-D) and catalase activities as well as ascorbic acid and TBARS levels were determined in the liver of rats. (PhSe)(2) protected against the increase in AST, ALT, ALP, LDH and gamma-GT activities induced by AA exposure to rats. The histological data showed that sections of liver from AA-exposed rats presented intense cellular necrosis, characterized by the presence of Kupffer cells and other infiltrating cells, mainly around of the centrilobular vein. (PhSe)(2) significantly attenuated AA-induced hepatic histopathological alterations. Administration of (PhSe)(2) protected against the increase in TBARS levels and the decrease in delta-ALA-D and GST activities as well as ascorbic acid content induced by AA exposure in rats. Catalase activity remained unaltered in all treated groups. The protective effect of (PhSe)(2) against hepatotoxicity caused by AA exposure in rats was demonstrated. |
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Authors:
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Ethel A Wilhelm; Cristiano R Jesse; Marlon R Leite; Cristina W Nogueira |
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Publication Detail:
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Type: Journal Article Date: 2009-01-21 |
Journal Detail:
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Title: Pathophysiology : the official journal of the International Society for Pathophysiology / ISP Volume: 16 ISSN: 0928-4680 ISO Abbreviation: Pathophysiology Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433813 Medline TA: Pathophysiology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 31-7 Citation Subset: - |
Affiliation:
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Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, CEP 97105-900, Santa Maria, RS, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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