Document Detail


Studies on preparation of a tick-borne encephalitis (TBE) vaccine from the Skalica strain.
MedLine Citation:
PMID:  2874729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diethylether-treated vaccine against tick-borne encephalitis (TBE) represents a new type vaccine consisting of lipid-free and antigenically efficient components instead of whole virus particles. The TBE virus strain designated Skalica was used for vaccine preparation. This strain is thermosensitive, produces small plaques under agar overlay, is nonpathogenic for adult white mice following subcutaneous (s.c.) application and causes threshold viraemia in host animals. The vaccine was harmless and immunogenic as evidenced by experiments on white mice. Antibodies to TBE virus strain Ir 13 present in human healthy population of a natural TBE focus showed similar levels when tested with the Skalica strain. The Skalica virus strain can be recommended for preparation of the vaccine against TBE.
Authors:
M Gresíková; M Sekeyová; K Marcinka; F Ciampor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta virologica     Volume:  30     ISSN:  0001-723X     ISO Abbreviation:  Acta Virol.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-09-23     Completed Date:  1986-09-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370401     Medline TA:  Acta Virol     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  243-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Viral / biosynthesis*
Cells, Cultured
Chick Embryo
Electrophoresis, Polyacrylamide Gel
Encephalitis Viruses, Tick-Borne / immunology*,  ultrastructure
Encephalitis, Tick-Borne / immunology*
Ether, Ethyl
Hemagglutination Inhibition Tests
Humans
Mice
Microscopy, Electron
Vaccines, Attenuated / immunology
Viral Vaccines / immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Vaccines, Attenuated; 0/Viral Vaccines; 60-29-7/Ether, Ethyl

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