Document Detail

Studies of postoperative transarterial infusion chemotherapy for liver metastasis of colorectal carcinoma after hepatectomy.
MedLine Citation:
PMID:  9684138     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: The aim of this study was to evaluate the efficacy of postoperative transarterial infusion chemotherapy (PTIC) for the prevention of metastatic liver cancer recurrence after hepatectomy following curative surgery for colorectal carcinoma. METHODOLOGY: Thirty-eight patients who underwent curative hepatectomy for metastatic liver cancer from colorectal carcinoma were studied. Ten out of the 38 patients received PTIC (experimental group) and 28 patients did not receive chemotherapy (control group). PTIC was performed with an intrahepatic indwelling catheter, which was set-up for 3 weeks and repeated 3 times in two monthly intervals. RESULTS: In the control group, no significant differences were observed in the survival between patients with a single hepatic nodule and those with multiple hepatic nodules. Between patients with hepatic tumors of more than 3 cm in diameter and those with tumors less than 3 cm, and between patients with tumors located at H1 and H2, no significant differences were seen, either. However, the 5-year survival rate of the patients with metachronous liver metastases was 90% which was significantly better than for those patients with synchronous liver tumors (p < 0.05). The 100% of 3- and 100% of 4-year survival rates of the experimental group were significantly better than the 60% and 47% respectively of the control group (p < 0.05). The non-recurrence rate in the remnant liver was also significantly better in the experimental group than that in the control group (p < 0.01). The adverse effect of this protocol was negligible. CONCLUSION: We conclude that PTIC improved the survival and non-recurrence rate in the remnant liver of the patients with liver metastases from colorectal cancer after hepatectomy, and was considered to be safe and an important protective factor for the prevention of recurrence of liver metastases after hepatectomy.
T Asahara; M Kikkawa; M Okajima; Y Ojima; K Toyota; H Nakahara; K Katayama; T Itamoto; S Marubayashi; E One; H Yahata; K Dohi; K Azuma; K Ito
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  45     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    1998 May-Jun
Date Detail:
Created Date:  1998-11-05     Completed Date:  1998-11-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  805-11     Citation Subset:  IM    
Second Department of Surgery, Hiroshima University School of Medicine, Japan.
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MeSH Terms
Aged, 80 and over
Colorectal Neoplasms / diagnosis,  therapy*
Combined Modality Therapy
Disease-Free Survival
Evaluation Studies as Topic
Hepatectomy / mortality
Infusions, Intra-Arterial
Liver Neoplasms / drug therapy*,  mortality,  secondary*,  surgery
Middle Aged
Neoplasm Recurrence, Local / prevention & control
Postoperative Care
Survival Rate
Treatment Outcome

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