Document Detail

Studies on the poisonous skin secretion of individual red bellied toads, Melanophryniscus montevidensis (Anura, Bufonidae), from Uruguay.
MedLine Citation:
PMID:  16157358     Owner:  NLM     Status:  MEDLINE    
Toads belonging to the genus Melanophryniscus contain toxic alkaloids in their skin. From six locations in south-eastern Uruguay 81 specimens of Melanophryniscusmontevidensis were collected. In whole animal methanolic extracts of individual specimens, alkaloids of the pumiliotoxin (PTX) group and indolizidines were identified by gas chromatography/mass spectrometry; the predominant component PTX 251D was assayed quantitatively. The PTX-content of the various toad populations was found to be highly variable among individual specimens as well as among the populations. Very high levels of PTX 251D were detected in toads of the western part of the collection area, whereas very low levels of this alkaloid were assayed in toads near the Brazilian border. Remarkably high concentrations of the non-alkaloid hydroquinone were found to be present in all toads. The analysis of extracts from 125 arthropod samples (Arachnida and Insecta, including termites, ants and beetles), which may represent a potential food source, revealed no alkaloids of the PTX group.
Dietrich Mebs; Werner Pogoda; Raul Maneyro; Axel Kwet
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-09-12
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  46     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-11     Completed Date:  2006-06-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  England    
Other Details:
Languages:  eng     Pagination:  641-50     Citation Subset:  IM    
Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D-60596 Frankfurt, Germany.
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MeSH Terms
Alkaloids / chemistry,  isolation & purification*
Amphibian Venoms / chemistry,  isolation & purification*
Bodily Secretions / chemistry*
Feces / chemistry
Gas Chromatography-Mass Spectrometry
Indolizines / chemistry,  isolation & purification*
Insects / chemistry
Microscopy, Electron, Scanning
Skin / anatomy & histology,  chemistry*
Reg. No./Substance:
0/Alkaloids; 0/Amphibian Venoms; 0/Indolizines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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