| Studies of the pharmacokinetics and metabolism of 4-amino-propiophenone (PAPP) in rats, dogs and cynomolgus monkeys. | |
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MedLine Citation:
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PMID: 1683551 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pharmacokinetics and metabolism of 4-aminopropiophenone (PAPP), a cyanide antidote, have been studied in rats, dogs and cynomolgus monkeys using 14C-PAPP. Radiolabelled material was rapidly excreted in all three species, mainly in urine. In rats, PAPP was metabolized by N-acetylation, while in dogs, ring and aliphatic hydroxylation occurred. In monkeys, both N-acetylation and oxidation took place. In the latter pathway, PAPP was oxidized to p-aminobenzoic acid which underwent amino acid-conjugation to p-aminohippuric acid. In rat blood in vitro, the PAPP metabolites, p-aminobenzoic, p-aminohippuric and N-acetyl-p-aminobenzoic acid were only weak methaemoglobin producers. |
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Authors:
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S G Wood; K Fitzpatrick; J E Bright; R H Inns; T C Marrs |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Human & experimental toxicology Volume: 10 ISSN: 0960-3271 ISO Abbreviation: Hum Exp Toxicol Publication Date: 1991 Sep |
Date Detail:
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Created Date: 1992-01-08 Completed Date: 1992-01-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9004560 Medline TA: Hum Exp Toxicol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 365-74 Citation Subset: IM |
Affiliation:
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Huntingdon Research Centre Ltd, Cambs, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Radioisotopes / diagnostic use Dogs Female Macaca fascicularis Male Propiophenones / pharmacokinetics*, urine Rats Rats, Inbred Strains Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Propiophenones; 70-69-9/4-aminopropiophenone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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