Document Detail

Studies on the phagocytic capacity of macrophage polykaryons.
MedLine Citation:
PMID:  338866     Owner:  NLM     Status:  MEDLINE    
Following the demonstration by Chambers (1977a,b and c) that simultaneous attachment of macrophages to endocytogenic material in vitro leads to fusion, as analysis of the phagocytic potential of giant cells has provided evidence that the same mechanism is operating in macrophage polykaryon formation in vovo. Unlike previously proposed models for macrophage fusion, fusion by simultaneous attempted endocytosis is associated with the interiorisation of surface membrane during fusion. This has been shown to have occurred during glass coverslip-induced fusion in vivo. Evidence has also been presented that it is the endocytogenic material produced in the granulomatous environment which leads to fusion, not necessarily the simulaneous attempted endocytosis of the implanted foreign material.
T J Chambers
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Journal of pathology     Volume:  123     ISSN:  0022-3417     ISO Abbreviation:  J. Pathol.     Publication Date:  1977 Oct 
Date Detail:
Created Date:  1978-02-18     Completed Date:  1978-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  65-77     Citation Subset:  IM    
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MeSH Terms
Cell Fusion
Cells, Cultured
Cytological Techniques
Macrophages / physiology*
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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