| Studies on the phagocytic capacity of macrophage polykaryons. | |
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MedLine Citation:
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PMID: 338866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Following the demonstration by Chambers (1977a,b and c) that simultaneous attachment of macrophages to endocytogenic material in vitro leads to fusion, as analysis of the phagocytic potential of giant cells has provided evidence that the same mechanism is operating in macrophage polykaryon formation in vovo. Unlike previously proposed models for macrophage fusion, fusion by simultaneous attempted endocytosis is associated with the interiorisation of surface membrane during fusion. This has been shown to have occurred during glass coverslip-induced fusion in vivo. Evidence has also been presented that it is the endocytogenic material produced in the granulomatous environment which leads to fusion, not necessarily the simulaneous attempted endocytosis of the implanted foreign material. |
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Authors:
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T J Chambers |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: The Journal of pathology Volume: 123 ISSN: 0022-3417 ISO Abbreviation: J. Pathol. Publication Date: 1977 Oct |
Date Detail:
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Created Date: 1978-02-18 Completed Date: 1978-02-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0204634 Medline TA: J Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 65-77 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Fusion Cells, Cultured Cricetinae Cytological Techniques Erythrocytes Latex Macrophages / physiology* Mice Microspheres Phagocytosis* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Latex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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