Document Detail

Studies on the pathophysiology and treatment of von Willebrand's disease. VI. Variant von Willebrand's disease complicating placenta previa.
MedLine Citation:
PMID:  6605595     Owner:  NLM     Status:  MEDLINE    
The clinical course of a pregnant patient with a variant form of von Willebrand's disease (type IIA) who was complicated with placenta previa totalis, breech presentation and premature delivery is described. Following whole blood transfusion, she underwent a cesarean section without postoperative hemorrhagic complications. Factor VIII/von Willebrand factor (FVIII/vWF)-related activities (factor VIII procoagulant activity [VIII:C], factor VIII-related antigen [VIIIR:Ag] and ristocetin cofactor [VIIIR:RCo]), Duke bleeding time and platelet retention to glass beads were monitored during pregnancy, labor and puerperium. Gradual increase in FVIII/vWF-related activities and shortening of bleeding time were found during her gestation. Platelet retention, however, remained low. Qualitative analysis of plasma FVIII/vWF with crossed immunoelectrophoresis and gel filtration on Sepharose 2B demonstrated that the large forms of FVIII/vWF, which is important for primary hemostasis, did not appear in the blood during gestation. Therefore, patients with type IIA von Willebrand's disease seem to be more susceptible to bleeding complications at delivery.
H Takahashi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Thrombosis research     Volume:  31     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  285-96     Citation Subset:  IM    
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MeSH Terms
Blood Coagulation Tests
Blood Transfusion
Cesarean Section
Genetic Variation
Placenta Previa / complications*
Pregnancy Complications, Hematologic*
von Willebrand Diseases / blood,  complications*,  genetics
von Willebrand Factor / analysis
Reg. No./Substance:
0/von Willebrand Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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