Document Detail

Studies on the pathogenesis of the erythrocyte destruction associated with the anemia of inflammatory disease.
MedLine Citation:
PMID:  15162326     Owner:  NLM     Status:  Publisher    
Density-separated feline RBC were analyzed for surface immunoglobulin and in vitro susceptibility to macrophage phagocytosis before and after introduction of a sterile abscess. Prior to abscess induction, least dense cells did not have detectable surface immunoglobulin G (IgG) as a direct antiglobulin reaction was negative. Two of four intermediate and three of four most dense cell fractions had detectable surface IgG as indicated by a positive direct antiglobulin reaction. On Days 3 and 5 after induction of sterile abscesses all three RBC fractions were positive and the size of the RBC clumps tended to increase. In vitro macrophage phagocytosis of all three RBC fractions increased significantly after abscess induction. The phagocytosis could be partially blocked by preincubation of macrophages with feline IgG.
D J Weiss; C B McClay
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary clinical pathology / American Society for Veterinary Clinical Pathology     Volume:  17     ISSN:  0275-6382     ISO Abbreviation:  Vet Clin Pathol     Publication Date:  1988  
Date Detail:
Created Date:  2004-05-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9880575     Medline TA:  Vet Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  90-3     Citation Subset:  -    
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota 55108.
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