Document Detail


Studies on the origin and generation of sympathetic nerve activity.
MedLine Citation:
PMID:  3242999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper summarizes the efforts of our laboratory to define the substrates and mechanisms for generation of one of the primary components in sympathetic nerve discharge (SND) of the cat, the 2- to 6-Hz rhythm. Using spike-triggered averaging, we have identified single brain stem neurons with naturally occurring activity correlated to the 2- to 6-Hz rhythm in SND. Such neurons were found in three regions--the rostral ventrolateral medulla (RVLM), medullary raphe (R) and medullary lateral tegmental field (LTF). RVLM neurons were inhibited in parallel to SND when carotid sinus pressure was raised while R neurons were excited. These observations suggest that RVLM neurons exert sympathoexcitatory (SE) actions while R neurons mediate sympathoinhibitory (SI) effects. Both SE and SI neurons were found in the LTF. Antidromic mapping revealed that the axons of RVLM-SE and R-SI neurons innervate the thoracic spinal intermediolateral nucleus. In contrast, LTF neurons do not project to the spinal cord. Rather, the axons of LTF-SE neurons project to the RVLM while those of LTF-SI neurons project to R. We hypothesize that the aforementioned cell groups comprise a network oscillator responsible for the 2- to 6-Hz rhythm in SND.
Authors:
G L Gebber; S M Barman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and experimental hypertension. Part A, Theory and practice     Volume:  10 Suppl 1     ISSN:  0730-0077     ISO Abbreviation:  Clin Exp Hypertens A     Publication Date:  1988  
Date Detail:
Created Date:  1989-05-30     Completed Date:  1989-05-30     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  8207790     Medline TA:  Clin Exp Hypertens A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  33-44     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Michigan State University, East Lansing 48824.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Stem / physiology*
Cats
Efferent Pathways / physiology
Electrophysiology
Raphe Nuclei / physiology
Sympathetic Nervous System / physiology*
Grant Support
ID/Acronym/Agency:
HL-13187/HL/NHLBI NIH HHS; HL-33266/HL/NHLBI NIH HHS

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