Document Detail

Studies on the neuropharmacology of tert-butylurea in mice.
MedLine Citation:
PMID:  1267534     Owner:  NLM     Status:  MEDLINE    
Tertiary butylurea has been investigated neuropharmacologically in mice and rats, and the results indicate that the compound possesses a marked CNS activity. It exhibited a pronounced activity against pentetrazole-induced convulsions and lethality, but the protection against strychnine-induced convulsions and lethality, was only partial. A significant prolongation of pentobarbital sleeping time by a subsedative dose of tert-butylurea was also observed. Protection afforded by tert-butylurea against tremorine-induced tremors and the intensity of its analgesic activity were both of moderate degree. In a subsedative dose range, tert-butylurea exhibited motor incoordination and behavioral effects with a decrease in the minor and the major movements of animals, as apparent from the treadmill and activity meter experiments respectively. The compound, however, does not seem to be a potent sedative-hypnotic agent, although there is a fairly good margin of safety between the hypnotic and the lethal dose orally. The anti-pentetrazole activity of tert-butylurea suggests its possible effectiveness against 'petit mal' seizures and, therefore, calls for additional studies to evaluate the anticonvulsant activity of tert-butylurea.
M S Dar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  219     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:  1976 Jan 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  103-15     Citation Subset:  IM    
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MeSH Terms
Analgesics / pharmacology
Anticonvulsants / pharmacology
Barbiturates / pharmacology
Drug Synergism
Hypnotics and Sedatives / pharmacology
Motor Activity / drug effects
Motor Skills / drug effects
Time Factors
Tremorine / antagonists & inhibitors
Urea / analogs & derivatives*,  pharmacology
Reg. No./Substance:
0/Analgesics; 0/Anticonvulsants; 0/Barbiturates; 0/Hypnotics and Sedatives; 51-73-0/Tremorine; 57-13-6/Urea

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