Document Detail


Studies on the nature of autoimmunity in myasthenia gravis. Evidence for an immunodeficiency type.
MedLine Citation:
PMID:  134659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinical and laboratory data continue to support the concept of a genetically determined breakdown of immunological tolerance in myasthenia gravis with immunological damage to the motor end plates. The demonstration of impaired function of thymus-derived lymphocytes and of IgA deficiency correlate well with the clinical data in which there is an increase incidence of autoimmune diseases associated with anergy. Whilst the exact pathogenesis of myasthenia gravis is unknown, the available data support the concept of an immune deficiency disorder.
Authors:
J A Simpson; P O Behan; H M Dick
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  274     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  1976  
Date Detail:
Created Date:  1976-10-20     Completed Date:  1976-10-20     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  382-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antibody Formation
Antigen-Antibody Reactions
Autoimmune Diseases / immunology*
Complement System Proteins / metabolism
Genes
HLA Antigens
Humans
Immune Tolerance
Immunity, Cellular
Immunoglobulins / metabolism
Immunologic Deficiency Syndromes / immunology*
Lectins / pharmacology
Lymphocyte Activation
Lymphocyte Culture Test, Mixed
Myasthenia Gravis / genetics,  immunology*
Protein Biosynthesis
T-Lymphocytes / immunology
Thymectomy
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/Immunoglobulins; 0/Lectins; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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