Document Detail

Studies on the mutagenic activity of ascorbic acid in vitro and in vivo.
MedLine Citation:
PMID:  6403856     Owner:  NLM     Status:  MEDLINE    
In vitro data are presented to show that ascorbic acid does not have intrinsic mutagenicity towards strain TA100 of S. typhimurium if deionized water is used to prepare the incubation medium. The addition of Cu2+ ions to the bacterial medium that contains ascorbic acid, or the use of tap water and ascorbic acid alone, causes a mutagenic and cytotoxic response that is blocked by EDTA. Additional in vitro data demonstrate that hydrogen peroxide is mutagenic to S. typhimurium strain TA100 and it is suggested that ascorbic acid may be mutagenic and cytotoxic through the generation of hydrogen peroxide. In vivo studies using a sensitive intrahepatic host-mediated mutagenicity assay indicate that ascorbic acid is not genotoxic in guinea pigs even when the dietary intake of vitamin C is above the level required for tissue saturation (5000 mg/kg body weight/day).
E P Norkus; W Kuenzig; A H Conney
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  117     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  183-91     Citation Subset:  IM    
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MeSH Terms
Ascorbic Acid / toxicity*
Copper / pharmacology
Edetic Acid / pharmacology
Guinea Pigs
Hydrogen Peroxide / toxicity
Mutagenicity Tests
Salmonella typhimurium / drug effects
Reg. No./Substance:
0/Mutagens; 50-81-7/Ascorbic Acid; 60-00-4/Edetic Acid; 7440-50-8/Copper; 7722-84-1/Hydrogen Peroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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