Document Detail


Studies of mutagenesis and neoplastic transformation by bivalent metal ions and ionizing radiation.
MedLine Citation:
PMID:  2905837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the influence of nontoxic concentrations of each of two essential (Zn++ and Mn++) and one nonessential (Ni++) bivalent metal ions on spontaneous and radiation-induced neoplastic transformation and specific gene mutations in mammalian cells. All three metals induced low levels of transformation in mouse BALB/3T3 cells but exerted no mutagenic effect in CHO cells (hprt locus) over a broad range of concentrations. Continuous incubation for 8 or 15 days with each of the metal ions did not enhance the frequency of cell killing, transformation, or mutations induced by acute exposure to x-rays. Zn++, however, had a small but consistent protective effect on the induction of all three endpoints by x-irradiation.
Authors:
J B Little; J M Frenial; J Coppey
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Teratogenesis, carcinogenesis, and mutagenesis     Volume:  8     ISSN:  0270-3211     ISO Abbreviation:  Teratog., Carcinog. Mutagen.     Publication Date:  1988  
Date Detail:
Created Date:  1989-03-02     Completed Date:  1989-03-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8100917     Medline TA:  Teratog Carcinog Mutagen     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  287-92     Citation Subset:  IM    
Affiliation:
Department of Cancer Biology, Harvard University School of Public Health, Boston, Massachusetts 02115.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Transformation, Neoplastic / drug effects*,  radiation effects*
Cells, Cultured
Magnesium / pharmacology*
Mice
Mutation*
Nickel / pharmacology*
Time Factors
Zinc / pharmacology*
Grant Support
ID/Acronym/Agency:
CA-47542/CA/NCI NIH HHS; ES-00002/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
7439-95-4/Magnesium; 7440-02-0/Nickel; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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