| Studies of mutagenesis and neoplastic transformation by bivalent metal ions and ionizing radiation. | |
| | |
MedLine Citation:
|
PMID: 2905837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We examined the influence of nontoxic concentrations of each of two essential (Zn++ and Mn++) and one nonessential (Ni++) bivalent metal ions on spontaneous and radiation-induced neoplastic transformation and specific gene mutations in mammalian cells. All three metals induced low levels of transformation in mouse BALB/3T3 cells but exerted no mutagenic effect in CHO cells (hprt locus) over a broad range of concentrations. Continuous incubation for 8 or 15 days with each of the metal ions did not enhance the frequency of cell killing, transformation, or mutations induced by acute exposure to x-rays. Zn++, however, had a small but consistent protective effect on the induction of all three endpoints by x-irradiation. |
| | |
Authors:
|
J B Little; J M Frenial; J Coppey |
Related Documents
:
|
20460697 - Improved transformation of the halo-tolerant yeast zygosaccharomyces rouxii by electrop... 3677047 - Cytogenetics of trophoblasts from complete hydatidiform moles. 19508357 - Histological and ultrastructural observation reveals significant cellular differences b... 15566957 - Hyperphosphorylation of extracellular regulated kinase 2 (erk2) and inhibition of jnk2 ... 14766227 - Expression cloning of functional receptor used by sars coronavirus. 19951197 - Intravenous route of cell delivery for treatment of neurological disorders: a meta-anal... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Teratogenesis, carcinogenesis, and mutagenesis Volume: 8 ISSN: 0270-3211 ISO Abbreviation: Teratog., Carcinog. Mutagen. Publication Date: 1988 |
Date Detail:
|
Created Date: 1989-03-02 Completed Date: 1989-03-02 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8100917 Medline TA: Teratog Carcinog Mutagen Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 287-92 Citation Subset: IM |
Affiliation:
|
Department of Cancer Biology, Harvard University School of Public Health, Boston, Massachusetts 02115. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Transformation, Neoplastic / drug effects*, radiation effects* Cells, Cultured Magnesium / pharmacology* Mice Mutation* Nickel / pharmacology* Time Factors Zinc / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
|
CA-47542/CA/NCI NIH HHS; ES-00002/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
7439-95-4/Magnesium; 7440-02-0/Nickel; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluation of sister chromatid exchange as an indicator of sensitivity to N-ethyl-N-nitrosourea-indu...
Next Document: Mutagenicity of topoisomerase-active agents in bacteriophage T4.