Document Detail

Studies on the morphologic and metabolic changes of human fat cells maintained in culture.
MedLine Citation:
PMID:  706999     Owner:  NLM     Status:  MEDLINE    
Specimens of human adipose tissue were maintained in vitro for one week and cell size as well as metabolic rates determined before and after the culture period. Large fat cells from obese donors decreased towards 'normal' cell size while this was not the case for cells from non-obese donors. This decrease was probably due to the increased lipolysis found while glucose incorporation was unchanged. Analogous to the findings with obese subjects placed on a weight-reducing regimen, the present data show that when large fat cells are removed from their anabolic, hyperinsulinic environment, 'normalization' in cell size occurs.
M Cigolini; B Jacobsson; G Nyberg; U Smith
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Acta diabetologica latina     Volume:  15     ISSN:  0001-5563     ISO Abbreviation:  Acta Diabetol Lat     Publication Date:    1978 May-Aug
Date Detail:
Created Date:  1978-12-20     Completed Date:  1978-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0123567     Medline TA:  Acta Diabetol Lat     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  152-8     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / cytology*,  metabolism
Cells, Cultured
Glucose / metabolism*
Glycerol / metabolism*
Lipid Metabolism*
Middle Aged
Obesity / metabolism*
Reg. No./Substance:
50-99-7/Glucose; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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