Document Detail

Studies on the mechanisms of glucocorticoid hypertension in humans.
MedLine Citation:
PMID:  8199716     Owner:  NLM     Status:  MEDLINE    
Hypertension is a common feature of both Cushing's syndrome, which is relatively rare, and iatrogenic steroid administration, which is much more common. Cardiovascular mortality and morbidity are very significant in patients with both naturally occurring and iatrogenic disease. The mechanism of glucocorticoid induced hypertension in man remains undefined. Contrary to previous notions, it does not reflect urinary sodium retention or volume expansion. Increased pressor responsiveness may be an important contributor to the rise in blood pressure.
J A Whitworth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Blood pressure     Volume:  3     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-07-01     Completed Date:  1994-07-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  24-32     Citation Subset:  IM    
Department of Medicine, St. George Hospital, University of New South Wales, Kogarah, Australia.
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MeSH Terms
Blood Vessels / drug effects,  physiopathology
Glucocorticoids* / metabolism,  pharmacology
Hemodynamics / drug effects
Hormones / physiology
Hydrocortisone / pharmacology
Hyperinsulinism / chemically induced,  complications
Hypertension / chemically induced*,  etiology
Plasma Volume
Sodium / metabolism
Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors
Sympathetic Nervous System / physiopathology
Reg. No./Substance:
0/Glucocorticoids; 0/Hormones; 50-23-7/Hydrocortisone; 7440-23-5/Sodium; EC ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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