Document Detail

Studies of the mechanism of the vasoconstrictor activity of stroma-free hemoglobin in the isolated perfused rat kidney and rabbit heart.
MedLine Citation:
PMID:  2622922     Owner:  NLM     Status:  MEDLINE    
We have found that DBBF-Hb and Hb Ao have significantly less vasoconstrictor activity than unmodified Hb in the rabbit heart. In striking contrast to these findings, DBBF-Hb and unmodified Hb have comparable hemodynamic effects in the isolated kidney. We have demonstrated that lipophilic contamination of fraction V BSA causes vasoconstriction in the coronary vasculature and speculate that similar contaminants may contribute to the vasoconstrictor activity of SFH solutions. Finally, we have shown that renal vasoconstriction induced by DBBF-Hb is reversed by acetylcholine as well as nitroprusside. These studies suggest that renal vasoconstriction induced by DBBF-Hb is not related to inhibition of EDRF. These studies make it clear that SFH solutions have different effects on the heart and kidney vasculature. The use of both heart and kidney models should provide important information on the mechanisms by which SFH causes vasoconstriction in these two organs.
W Lieberthal; W M Vogel; C S Apstein; C R Valeri
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Progress in clinical and biological research     Volume:  319     ISSN:  0361-7742     ISO Abbreviation:  Prog. Clin. Biol. Res.     Publication Date:  1989  
Date Detail:
Created Date:  1990-03-19     Completed Date:  1990-03-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605701     Medline TA:  Prog Clin Biol Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  407-20; discussion 421-2     Citation Subset:  IM    
Renal Section, Boston University School of Medicine, MA 02118.
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MeSH Terms
Acetylcholine / pharmacology
Aspirin / analogs & derivatives
Coronary Vessels / drug effects*
Cross-Linking Reagents
Hemoglobins / pharmacology*
Phosphatidylethanolamines / pharmacology
Phosphatidylserines / pharmacology
Plasma Substitutes / pharmacology*
Rats, Inbred Strains
Renal Circulation / drug effects*
Serum Albumin, Bovine / pharmacology
Vasoconstriction / drug effects*
Vasoconstrictor Agents / pharmacology*
Reg. No./Substance:
0/Cross-Linking Reagents; 0/Hemoglobins; 0/Phosphatidylethanolamines; 0/Phosphatidylserines; 0/Plasma Substitutes; 0/Serum Albumin, Bovine; 0/Vasoconstrictor Agents; 0/hemoglobin, stroma free; 15078-28-1/Nitroprusside; 50-78-2/Aspirin; 51-84-3/Acetylcholine; 71337-53-6/bis(3,5-dibromosalicyl)fumarate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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