| Studies on the mechanism of leukotriene induced coronary artery constriction. | |
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MedLine Citation:
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PMID: 6318273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leukotriene (LT) C4, D4, and E4 at concentrations of 10 to 100 ng/ml were found to be potent coronary artery constrictors in the perfused cat coronary artery and perfused rat heart. In contrast, LTB4, was essentially inactive. The coronary constrictor effect of leukotrienes was not related to thromboxane release, but rather appeared to be due to a calcium mediated activation of specific leukotriene receptors. |
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Authors:
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D M Roth; A M Lefer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prostaglandins Volume: 26 ISSN: 0090-6980 ISO Abbreviation: Prostaglandins Publication Date: 1983 Oct |
Date Detail:
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Created Date: 1984-02-14 Completed Date: 1984-02-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0320271 Medline TA: Prostaglandins Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 573-81 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cats Coronary Vessels / drug effects* Dose-Response Relationship, Drug Heart / drug effects Leukotriene E4 Male Perfusion Rats SRS-A / analogs & derivatives*, pharmacology* Vasoconstriction / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/SRS-A; 75715-89-8/Leukotriene E4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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