Document Detail


Studies on the mechanism of leukotriene induced coronary artery constriction.
MedLine Citation:
PMID:  6318273     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leukotriene (LT) C4, D4, and E4 at concentrations of 10 to 100 ng/ml were found to be potent coronary artery constrictors in the perfused cat coronary artery and perfused rat heart. In contrast, LTB4, was essentially inactive. The coronary constrictor effect of leukotrienes was not related to thromboxane release, but rather appeared to be due to a calcium mediated activation of specific leukotriene receptors.
Authors:
D M Roth; A M Lefer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins     Volume:  26     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  573-81     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cats
Coronary Vessels / drug effects*
Dose-Response Relationship, Drug
Heart / drug effects
Leukotriene E4
Male
Perfusion
Rats
SRS-A / analogs & derivatives*,  pharmacology*
Vasoconstriction / drug effects*
Chemical
Reg. No./Substance:
0/SRS-A; 75715-89-8/Leukotriene E4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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