Document Detail


Studies on the mechanism of the hypotensive action of SQ-14225, an angiotensin-converting enzyme inhibitor in anesthetized dogs.
MedLine Citation:
PMID:  228363     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intravenous administration of SQ-14225, an angiotensin-converting enzyme inhibitor, to pentobarbital-anesthetized dogs resulted in significant decrease in the arterial blood pressure with no changes in the heart rate. Pressure-flow curves obtained in the perfused hind limb vasculature were shifted significantly to the right following SQ-14225 indicating a decrease in the hind limb vascular resistance. Neither the denervation of the hind limb nor bilateral nephrectomy prevented the decrease in the hind limb vascular resistance produced by SQ-14225 indicating that the vasodilator action of this agent was unrelated to either the sympathetic nervous system or the renal renin-angiotensin system. The reflex vasodilatation in the hind limb observed during the administration of pressor agents was significantly attenuated by SQ-14225. Similarly this agent also antagonized the reflex increases in the systemic blood pressure, hind limb perfusion pressure and heart rate observed during bilateral carotid occlusion. These results suggest that the hypotensive action of SQ-14225 in the pentobarbital-anesthetized dog may be unrelated to the renal renin-angiotensin system.
Authors:
B S Jandhyala; P Nandiwada; J P Buckley; M F Lokhandwala
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  25     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1980-01-19     Completed Date:  1980-01-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  429-46     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Angiotensin-Converting Enzyme Inhibitors*
Animals
Antihypertensive Agents*
Blood Pressure / drug effects
Captopril / pharmacology*
Dogs
Hindlimb / blood supply
Nephrectomy
Pentobarbital / pharmacology
Proline / analogs & derivatives*
Regional Blood Flow / drug effects
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 147-85-3/Proline; 62571-86-2/Captopril; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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