Document Detail


Studies on the mechanism of esophagitis-induced lower esophageal sphincter hypotension in cats.
MedLine Citation:
PMID:  1278649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Perfusion of 0.1 n HC1 5 cm above the lower esophageal sphincter (LES) in cats for 30 min on 4 consecutive days produced biopsy-documented esophagitis and marked decreases in LES pressure. Using this model the effects of experimental esophagitis on the LES response to edrophonium, pentagastrin, and bethanechol were determined. The sphincter response to both edrophonium and pentagastrin after esophagitis was induced was significantly less than preperfusion responses. When the esophagitis had resolved, the pressure response to edrophonium and pentagastrin returned to preperfusion levels. In contrast, the sphincter response to bethanechol during esophagitis was not different from the preperfusion response and remained unchanged after resolution of the esophagitis. Lower esophageal smooth muscle taken from cats with active esophagitis appeared normal by both light and electron microscopy. These studies indicate that besides decreasing resting LES tone, esophageal inflammation causes functional impairment of a cholinergic mechanism regulating LES pressure. In contrast, the smooth muscle appears to be unaffected by inflammation despite the LES hypotension.
Authors:
R H Higgs; D O Castell; G L Eastwood
Related Documents :
12646419 - Role of 5-ht1b/d receptors in canine gastric accommodation: effect of sumatriptan and 5...
12074039 - Pneumatosis cystoides intestinalis, four cases of a rare disease.
3348529 - Anal sphincter pressure and the rectosphincteric reflex in the dog.
11787959 - The normal antireflux mechanism.
15690669 - Relation between anal electrosensitivity and rectal filling sensation and the influence...
8724019 - Hyperglycaemia affects proximal gastric motor and sensory function in normal subjects.
2733029 - Total ischemia iii: effect of inhibition of anaerobic glycolysis.
21719729 - Blood pressure changes alter tracheobronchial cough: computational model of the respira...
1909499 - Effect of local ph on interstitial fluid pressure.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastroenterology     Volume:  71     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1976 Jul 
Date Detail:
Created Date:  1976-09-01     Completed Date:  1976-09-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  51-6     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Bethanechol Compounds / pharmacology
Cats
Disease Models, Animal
Edrophonium / pharmacology
Esophagitis / complications*
Esophagogastric Junction / drug effects,  physiopathology*
Esophagus / pathology
Mucous Membrane / pathology
Muscle, Smooth / ultrastructure
Pentagastrin / pharmacology
Pressure
Chemical
Reg. No./Substance:
0/Bethanechol Compounds; 312-48-1/Edrophonium; 5534-95-2/Pentagastrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The mechanism of hypergastrinemia in achlorhydria. Effect of food, acid, and calcitonin on serum gas...
Next Document:  Giardiasis in the mouse: an animal model.