Document Detail

Studies on the mechanism of esophagitis-induced lower esophageal sphincter hypotension in cats.
MedLine Citation:
PMID:  1278649     Owner:  NLM     Status:  MEDLINE    
Perfusion of 0.1 n HC1 5 cm above the lower esophageal sphincter (LES) in cats for 30 min on 4 consecutive days produced biopsy-documented esophagitis and marked decreases in LES pressure. Using this model the effects of experimental esophagitis on the LES response to edrophonium, pentagastrin, and bethanechol were determined. The sphincter response to both edrophonium and pentagastrin after esophagitis was induced was significantly less than preperfusion responses. When the esophagitis had resolved, the pressure response to edrophonium and pentagastrin returned to preperfusion levels. In contrast, the sphincter response to bethanechol during esophagitis was not different from the preperfusion response and remained unchanged after resolution of the esophagitis. Lower esophageal smooth muscle taken from cats with active esophagitis appeared normal by both light and electron microscopy. These studies indicate that besides decreasing resting LES tone, esophageal inflammation causes functional impairment of a cholinergic mechanism regulating LES pressure. In contrast, the smooth muscle appears to be unaffected by inflammation despite the LES hypotension.
R H Higgs; D O Castell; G L Eastwood
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastroenterology     Volume:  71     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1976 Jul 
Date Detail:
Created Date:  1976-09-01     Completed Date:  1976-09-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  51-6     Citation Subset:  AIM; IM    
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MeSH Terms
Bethanechol Compounds / pharmacology
Disease Models, Animal
Edrophonium / pharmacology
Esophagitis / complications*
Esophagogastric Junction / drug effects,  physiopathology*
Esophagus / pathology
Mucous Membrane / pathology
Muscle, Smooth / ultrastructure
Pentagastrin / pharmacology
Reg. No./Substance:
0/Bethanechol Compounds; 312-48-1/Edrophonium; 5534-95-2/Pentagastrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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