| Studies of the mechanism of action of urethane in initiating pulmonary adenomas in mice. II. Its relation to nucleic acid synthesis. | |
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MedLine Citation:
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PMID: 13416469 Owner: NLM Status: OLDMEDLINE |
Abstract/OtherAbstract:
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The process of carcinogenesis following exposure of mice to urethane is demonstrated in the present work to be intimately related to nucleic acid synthesis. Injection of animals with a DNA hydrolysate immediately prior to a single exposure of the animals to urethane markedly reduced the number of pulmonary adenomas initiated. Aminopterin, known to interfere in nucleic acid synthesis (46), potentiated the carcinogenic action of urethane and this potentiation was blocked by injection of a DNA hydrolysate. Of the components and precursors of nucleic acids the pyrimidine series seemed especially concerned. Alterations in the utilization of oxaloacetate, ureidosuccinic acid, dihydro-orotic acid, orotic acid, cytidylic acid, and thymine appeared to be critical steps in the oncogenic process, following upon the primary disorder of cellular metabolism initiated by the carcinogen. All these substances except oxaloacetate profoundly reduced the number of tumors initiated by urethane. Oxaloacetate potentiated the carcinogenic effect. When these results are viewed together and in relation to known facts concerning nucleic acid synthesis they provide evidence suggesting that the point of action of the carcinogen is in the pathway of nucleic acid synthesis below orotic acid and perhaps at the level of ureidosuccinic acid. The potentiating influence of adenine, 4-amino-5-imidazole carboxamide, and aminopterin, the lack of effect of uracil, and the inhibitory influence of thymine together suggest that DNA rather than RNA is the nucleic acid critical to the oncogenic response of mice to urethane. |
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Authors:
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S ROGERS |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of experimental medicine Volume: 105 ISSN: 0022-1007 ISO Abbreviation: J. Exp. Med. Publication Date: 1957 Apr |
Date Detail:
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Created Date: 1957-12-01 Completed Date: 2002-05-01 Revised Date: 2010-09-21 |
Medline Journal Info:
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Nlm Unique ID: 2985109R Medline TA: J Exp Med Country: Not Available |
Other Details:
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Languages: eng Pagination: 279-306 Citation Subset: OM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Neoplasms
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metabolism* Nucleic Acids / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acids |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Exp Med ISSN: 0022-1007 ISSN: 1540-9538 Publisher: The Rockefeller University Press |
Article Information Download PDF  Copyright © Copyright, 1957, by The Rockefeller Institute for Medical Research New York Received Day: 19 Month: 12 Year: 1956 Print publication date: Day: 31 Month: 3 Year: 1957 Volume: 105 Issue: 4 First Page: 279 Last Page: 306 ID: 2136699 PubMed Id: 13416469 |
| STUDIES OF THE MECHANISM OF ACTION OF URETHANE IN INITIATING PULMONARY ADENOMAS IN MICE : II. ITS RELATION TO NUCLEIC ACID SYNTHESIS | |
| Stanfield Rogers | |
| From the Department of Pathology, Duke University School of Medicine, Durham |
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