Document Detail


Studies on the mechanism of action of miconazole: effect of miconazole on respiration and cell permeability of Candida albicans.
MedLine Citation:
PMID:  15825399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The antifungal drug, miconazole nitrate, inhibits the growth of several species of Candida. Candida albicans, one of the pathogenic species, was totally inhibited at a concentration of approximately 10 mug/ml. Endogenous respiration was unaffected by the drug at a concentration as high as 100 mug/ml, whereas exogenous respiration was markedly sensitive and inhibited to an extent of 85%. The permeability of the cell membrane was changed as evidenced by the leakage of 260-nm absorbing materials, amino acids, proteins, and inorganic cations. The results we present clearly show that the drug alters the cellular permeability, and thus the exogenous respiration becomes sensitive to the drug.
Authors:
K H Sreedhara Swamy; M Sirsi; G R Ramananda Rao
Related Documents :
8821599 - Treatment of experimental systemic mycoses with brl 49594a.
16005979 - Thiourea, triazole and thiadiazine compounds and their metal complexes as antifungal ag...
23264949 - Formulation and characterization of benzoyl peroxide gellified emulsions.
18039919 - In vitro antifungal susceptibilities of five species of sporothrix.
10859429 - Comparative in vitro antifungal activity of amphotericin b lipid complex, amphotericin ...
6194399 - The effect of ay-9944 on yeast sterol and sterol ester metabolism.
9506339 - Effect of intracoronary balloon inflation at percutaneous transluminal coronary angiopl...
11248359 - Genetic risks of antiviral nucleoside analogues--a survey.
6890359 - Pharmacological evaluation of minaprine dihydrochloride, a new psychotropic drug.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  5     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1974 Apr 
Date Detail:
Created Date:  2005-04-13     Completed Date:  2005-05-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  420-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / pharmacology*
Candida albicans / drug effects*,  growth & development
Cations, Divalent / pharmacology
Drug Interactions
Drug Resistance, Fungal
Energy Metabolism / drug effects
Miconazole / pharmacology*
Permeability / drug effects
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Cations, Divalent; 22916-47-8/Miconazole
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Enhanced toxicity for mice of 6-mercaptopurine with bacterial endotoxin.
Next Document:  Effect of certain polypeptides on the biological activities of Measles virus.