Document Detail

Studies on the mechanism of action of miconazole: effect of miconazole on respiration and cell permeability of Candida albicans.
MedLine Citation:
PMID:  15825399     Owner:  NLM     Status:  MEDLINE    
The antifungal drug, miconazole nitrate, inhibits the growth of several species of Candida. Candida albicans, one of the pathogenic species, was totally inhibited at a concentration of approximately 10 mug/ml. Endogenous respiration was unaffected by the drug at a concentration as high as 100 mug/ml, whereas exogenous respiration was markedly sensitive and inhibited to an extent of 85%. The permeability of the cell membrane was changed as evidenced by the leakage of 260-nm absorbing materials, amino acids, proteins, and inorganic cations. The results we present clearly show that the drug alters the cellular permeability, and thus the exogenous respiration becomes sensitive to the drug.
K H Sreedhara Swamy; M Sirsi; G R Ramananda Rao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  5     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1974 Apr 
Date Detail:
Created Date:  2005-04-13     Completed Date:  2005-05-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  420-5     Citation Subset:  IM    
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MeSH Terms
Antifungal Agents / pharmacology*
Candida albicans / drug effects*,  growth & development
Cations, Divalent / pharmacology
Drug Interactions
Drug Resistance, Fungal
Energy Metabolism / drug effects
Miconazole / pharmacology*
Permeability / drug effects
Reg. No./Substance:
0/Antifungal Agents; 0/Cations, Divalent; 22916-47-8/Miconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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