| Studies on the mechanism of absorption and distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. | |
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MedLine Citation:
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PMID: 3795035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), the toxic contaminant of Agent Orange, is absorbed essentially by the lymphatic route and is transported predominantly by chylomicrons after intestinal absorption. Plasma disappearance of [3H]TCDD-labeled chylomicrons followed first-order decay kinetics, with two exponential components having half-lives of 0.8 and 30 min, respectively. Liver and adipose tissues together accounted for 74 to 81% of the total radioactivity distributed among various tissues. The i.p. route of administration was as effective as the oral route for uptake in 24 h by the adipose and liver tissues, whereas the s.c. route was less efficient. Adipose tissue exhibited a progressive accumulation of labeled TCDD during the first 24 h, whereas the liver showed an exponential disappearance of the newly absorbed TCDD with a half-life of 21.3 h. In contrast, long-term pharmacokinetics of TCDD in the adipose and liver tissues revealed exponential decay patterns with half-lives of 7.6 and 5.3 weeks, respectively. These results show that the adipose tissue and the liver are the major sites of TCDD storage. |
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Authors:
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M R Lakshmanan; B S Campbell; S J Chirtel; N Ekarohita; M Ezekiel |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The Journal of pharmacology and experimental therapeutics Volume: 239 ISSN: 0022-3565 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 1986 Dec |
Date Detail:
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Created Date: 1987-01-30 Completed Date: 1987-01-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 673-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism Animals Chylomicrons / metabolism Dioxins / metabolism* Half-Life Intestinal Absorption* Kinetics Lymphatic System / metabolism Male Rats Rats, Inbred Strains Tetrachlorodibenzodioxin / metabolism* Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Chylomicrons; 0/Dioxins; 1746-01-6/Tetrachlorodibenzodioxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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