Document Detail

Studies on the mechanism of DDT resistance in Culex pipiens fatigans. Lipids of susceptible and resistant strains.
MedLine Citation:
PMID:  5310957     Owner:  NLM     Status:  MEDLINE    
The mechanism of DDT resistance in Culex pipiens fatigans is poorly understood. Earlier studies indicated that the dehydrochlorination of DDT does not explain resistance in this species. Studies on the role of lipids as a mechanism of resistance included the estimation of lipid content and the determination of the proportions of different classes of lipids in the larvae of susceptible and resistant strains. There was no evidence of any correlation between the lipid content and DDT resistance in this species and the proportions of neutral lipids, phospholipids and fatty acids of different strains did not indicate any consistent correlation with DDT resistance.Within one strain, the larvae containing the higher amount of lipids were able to resist better the toxic effect of DDT. Analysis of fatty acids of the larvae that survived and died as a result of treatment with DDT did not reveal any difference.Neither p,p'-DDT nor o,p'-DDT at sublethal concentration affected the lipids of the larvae of susceptible and resistant strains.
R L Kalra
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of the World Health Organization     Volume:  42     ISSN:  0042-9686     ISO Abbreviation:  Bull. World Health Organ.     Publication Date:  1970  
Date Detail:
Created Date:  1970-09-19     Completed Date:  1970-09-19     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  7507052     Medline TA:  Bull World Health Organ     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  623-9     Citation Subset:  IM    
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MeSH Terms
Chromatography, Gas
Chromatography, Thin Layer
Fatty Acids / analysis
Insecticide Resistance*
Larva / analysis
Lipids / analysis*
Phospholipids / analysis
Species Specificity
Reg. No./Substance:
0/Fatty Acids; 0/Lipids; 0/Phospholipids; 50-29-3/DDT

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