| Studies of luminal and mucosal pH in reflux esophagitis and antral gastritis. | |
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MedLine Citation:
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PMID: 1611709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Luminal and mucosal pH were measured endoscopically in patients with reflux esophagitis and antral gastritis and in control subjects. In all subjects, significant lumen-to-mucosa gradients were observed in the esophagus, stomach and acidified proximal duodenum. In the reflux patients luminal pH was lower in the fundus (mean +/- SEM, control vs. reflux esophagitis: 2.01 +/- 0.17 vs. 1.32 +/- 0.18; p less than 0.02) and antrum (3.51 +/- 0.35 vs. 2.13 +/- 0.24; p less than 0.01) and, in the gastritis patients, in the fundus (2.01 +/- 0.17 vs. 1.3 +/- 0.17; p less than 0.02). In both patient groups, mucosal pH was lower in the fundus (control vs. reflux vs. gastritis: 4.84 +/- 0.37 vs. 3.37 +/- 0.61 vs. 3.12 +/- 0.6; p less than 0.05) and acidified duodenal cap (6.74 +/- 0.13 vs. 6.09 +/- 0.24 vs. 5.73 +/- 0.46; p less than 0.03). Mucosal pH profiles at the various sites showed less resistance of the gradient to a highly acidic environment in both the lower esophagus and antrum than in fundus and duodenum, and this was the case in the patient and control groups. Though associated with a more acid environment, neither esophagitis nor antral gastritis exhibits a specific deficit in the 'mucus-bicarbonate barrier', suggesting that the pathogenesis of these disorders may depend more on abnormal 'attack' rather than impaired defense. |
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Authors:
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E M Quigley; L A Turnberg |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Digestive diseases (Basel, Switzerland) Volume: 10 ISSN: 0257-2753 ISO Abbreviation: Dig Dis Publication Date: 1992 |
Date Detail:
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Created Date: 1992-07-30 Completed Date: 1992-07-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701186 Medline TA: Dig Dis Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 134-43 Citation Subset: IM |
Affiliation:
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University Department of Medicine, Hope Hospital (University of Manchester Medical School), Salford, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Endoscopy Esophagitis, Peptic / etiology*, physiopathology Esophagus / physiology* Female Gastric Mucosa / physiology Gastritis / etiology*, physiopathology Humans Hydrogen-Ion Concentration* Male Middle Aged Pyloric Antrum Stomach / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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