| Studies on the kinetics of unconjugated [14C]bilirubin metabolism in normal subjects and patients with compensated cirrhosis. | |
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MedLine Citation:
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PMID: 884928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The kinetics of unconjugated [14C]-bilirubin metabolism have been investigated and analysed in terms of a three-pool model in a group of seven normal subjects and in a group of eight cirrhotic patients who had appreciable impairment of liver cell function. 2. In the patients with cirrhosis, the plasma unconjugated bilirubin was either normal or only slightly increased but the metabolism of unconjugated bilirubin was deranged. 3. The mean volume of distribution, the mean 4 h retention, and the mean mass of the rapidly mixing pool were all significantly greater than in the normal subjects. In contrast, mean fractional clearance rate and mean estimated erythrocyte life-span were significantly less than in the normal subjects. 4. The mean functional transfer rates and fluxes from pool 1 (rapidly mixing pool--'plasma') to pool 3 ('extravascular') and vice versa were significantly greater than the corresponding values in the normal subjects. 5. The results indicate that, in patients with compensated cirrhosis, the efficiency of the liver in extracting unconjugated bilirubin from plasma against a concentration gradient is impaired, even though the liver's capacity to conjugate bilirubin may be normal. As a consequence of the increased volume of distribution, the absolute hepatic clearance of unconjugated bilirubin is relatively well maintained. |
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Authors:
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D Owens; E A Jones; E R Carson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical science and molecular medicine Volume: 52 ISSN: 0301-0538 ISO Abbreviation: Clin Sci Mol Med Publication Date: 1977 Jun |
Date Detail:
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Created Date: 1977-09-22 Completed Date: 1977-09-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0367540 Medline TA: Clin Sci Mol Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 555-70 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bilirubin
/
blood,
metabolism* Blood Volume Carbon Radioisotopes Female Humans Kinetics Liver Cirrhosis / metabolism* Male Models, Biological |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 635-65-4/Bilirubin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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