Document Detail


Studies on the kinetics and renal excretion of low and high molecular weight dextrans in preterm babies, newborns and young infants.
MedLine Citation:
PMID:  885145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Administration of low and high molecular weight dextrans in the initial phase of shock is no longer controversial. The special conditions in newborns, however, have been insufficiently considered in planning therapy. This investigation aimed at determining the biological half-lives of dextran 40 (Rheomacrodex) and dextran 60 (Macrodex) in this age group. The half-life of dextran 40 was found to be 60 min and that of dextran 60 3 h. Preterm babies and newborns excrete up to 25% less dextran 40 and 60 in 24 h than infants and adults. Normal adult values for excretion are only reached towards the end of the first year of life.
Authors:
P Emmrich; W Baumann; U Stechele
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pediatrics     Volume:  125     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-09-22     Completed Date:  1977-09-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  181-90     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Body Weight
Dextrans / metabolism*,  urine
Half-Life
Humans
Infant
Infant, Newborn
Infant, Premature
Infant, Small for Gestational Age
Kinetics
Molecular Weight
Chemical
Reg. No./Substance:
9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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