| Studies on the kinetics of melatonin and N-acetylserotonin in the rat at mid-light and mid-dark. | |
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MedLine Citation:
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PMID: 6545818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The distribution and disappearance of melatonin and N-acetylserotonin after intravenous injection were studied at mid-light and mid-dark. Male rats were adapted under a photoperiod of 12 h light and 12 h dark cycle for a minimum of 1 week. After the intravenous injection of melatonin (10 micrograms), N-acetylserotonin (10 micrograms), or 3H-melatonin (76 ng), blood samples were collected at 1, 3, 5, 10, 20, 30, 45, 60, 75, 90, and 120 min. The concentrations of indoles in the plasma samples were determined by radioimmunoassay, while the radioactivity of 3H-melatonin was determined by scintillation counting. The distribution of melatonin and N-acetylserotonin followed a two-compartment model, showing an initial distribution phase followed by an elimination phase. The biological half-life of melatonin at mid-light and mid-dark were similar but the volume of distribution (V beta and Vc) and metabolic clearance rate (C1s) were greater at mid-dark than at mid-light. The estimated melatonin secretory rate at mid-dark was fivefold greater than that at mid-light. When 3H-melatonin was used, the half-life was significantly longer. A diurnal difference in the distribution was also evident in the N-acetylserotonin studies. The volume of distribution (V beta and Vc) was greater at mid-dark while the C1s was not significantly faster at mid-dark compared with that at mid-light. However, the estimated N-acetylserotonin secretory rate at mid-dark was eightfold greater than at mid-light. |
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Authors:
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M Y Chan; S F Pang; P L Tang; G M Brown |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pineal research Volume: 1 ISSN: 0742-3098 ISO Abbreviation: J. Pineal Res. Publication Date: 1984 |
Date Detail:
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Created Date: 1986-05-01 Completed Date: 1986-05-01 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8504412 Medline TA: J Pineal Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 227-36 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Circadian Rhythm* Darkness Injections, Intravenous Kinetics Light Male Melatonin / administration & dosage, blood* Radioimmunoassay Rats Rats, Inbred Strains Serotonin / administration & dosage, analogs & derivatives*, blood |
| Chemical | |
Reg. No./Substance:
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1210-83-9/N-acetylserotonin; 50-67-9/Serotonin; 73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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