Document Detail


Studies on kinetics of anturan excretion in man.
MedLine Citation:
PMID:  489196     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The kinetics of anturan excretion was studied. Experiments were carried out on ten healthy volunteers. The drug was given orally once applying three different doses: 100, 200, 400 mg. The contents of the drug in urine were determined by means of the modified method worked out by Wallace. It was found about 42 per cent of the dose was excreted with urine in an unchanged form. The process of anturan excretion may be described according to the one-compartment open kinetic model. The half-life of excretion is 3.5 hours, the excretion constant is 0.20. The formula showing the course of anturan excretion in time has been given. Five examples of the quantitative exposure test have been proposed; they allow the calculation of the absorbed drug dose and thus the degree of poisoning. The test can be also helpful in controlled therapy.
Authors:
W Seńczuk; J Jodynis-Liebert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology and biopharmacy     Volume:  17     ISSN:  0340-0026     ISO Abbreviation:  Int J Clin Pharmacol Biopharm     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-12-18     Completed Date:  1979-12-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505527     Medline TA:  Int J Clin Pharmacol Biopharm     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  303-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Female
Half-Life
Humans
Kinetics
Male
Sex Factors
Sulfinpyrazone / urine*
Time Factors
Chemical
Reg. No./Substance:
57-96-5/Sulfinpyrazone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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