Document Detail

Studies on iron metabolism in sickle cell anaemia, sickle cell haemoglobin C disease, and haemoglobin C disease using a large volume liquid scintillation counter.
MedLine Citation:
PMID:  5423947     Owner:  NLM     Status:  MEDLINE    
Iron absorption as measured by a faecal recovery method in young adult males living in a tropical zone was high, even in the absence of anaemia. There was an inverse relation between the iron absorption and the packed cell volume. The highest absorption was found in sickle cell anaemia patients, where the packed cell volume is the lowest. The incorporation of iron was also the fastest and greatest in this group. In the controls the iron absorbed accumulated in the marrow and the spleen on the first day; in the sickle cell anaemia group the spleen has an insignificant role in iron storage. The growing radioactivity in the liver parallels that of the heart in the group of sickle cell anaemia patients; however, it remains low in the spleen in the same group, implying a diminution of splenic blood flow. In the sickle cell haemoglobin C and the haemoglobin C patients, the liver and spleen have an intermediate position between that of the sickle cell anaemia group and the control group.
B Ringelhann; F Konotey-Ahulu; S R Dodu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  23     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1970 Mar 
Date Detail:
Created Date:  1970-08-10     Completed Date:  1970-08-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  127-34     Citation Subset:  AIM; IM    
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MeSH Terms
Anemia, Sickle Cell / metabolism*
Bone Marrow / metabolism
Hemoglobin C*
Hemoglobin C Disease / metabolism
Hemoglobinopathies / metabolism*
Intestinal Absorption
Iron / blood,  metabolism*
Iron Isotopes
Liver / metabolism
Middle Aged
Myocardium / metabolism
Spleen / blood supply,  metabolism
Reg. No./Substance:
0/Iron Isotopes; 7439-89-6/Iron; 9008-00-8/Hemoglobin C

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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