Document Detail

Studies on intrapulmonary gas distribution in the normal subject. Influence of anaesthesia and artificial ventilation.
MedLine Citation:
PMID:  484186     Owner:  NLM     Status:  MEDLINE    
Intrapulmonary gas distribution, assessed by a multiple breath, nitrogen washout technique and expressed by the Fowler index NWOD, was studied in subjects with healthy lungs during spontaneous breathing while awake, and during mechanical ventilation under halothane anaesthesia. The distribution index rose from a mean of 32% awake to 56% during anaesthesia. An attempt was also made to differentiate between the contribution of gravitational (airway closure) and non-gravitational (diffuse airway obstruction) inhomogeneity of ventilation. This was accomplished by measurement of the slope of the alveolar plateau during a sinle breath nitrogen washout. The slope was similar awake and anaesthetized, and it increased equally under both conditions, when preinspiratory lung volume was stepped up from RV to CC, CC being the lung volume at which airways begin to close during expiration. NWOD was significantly correlated to the degree of airway closure, expressed as FRC-CC, and, less so, to inspiratory resistance. It is suggested that a less efficient ventilation distribution in anaesthetized normal subjects, as measured by NWOD, is caused rather by airway closure (gravitational inhomogeneity) than by diffuse airway obstruction (non-gravitational inhomogeneity of ventilation).
G Hedenstierna; J Santesson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  23     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-11-28     Completed Date:  1979-11-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  291-9     Citation Subset:  IM    
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MeSH Terms
Airway Resistance
Anesthesia, General*
Lung Volume Measurements
Middle Aged
Nitrogen / analysis
Oxygen / analysis
Respiration, Artificial*
Tidal Volume
Reg. No./Substance:
151-67-7/Halothane; 7727-37-9/Nitrogen; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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