| Studies on intragastric PCO2 at rest and during exercise as a marker of intestinal perfusion in patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 15182764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The aim of this study was to investigate mesenteric ischaemia by determining intragastric PCO(2) (iPCO(2)) with gastric tonometry during rest and exercise stress testing in patients with chronic heart failure (CHF). In CHF inflammatory immune activation is hypothesized to result from a chronic endotoxin challenge due to bacterial translocation of hypoperfused intestinal mucosa. METHODS AND RESULTS: In 10 patients with CHF and ten healthy controls a tonometry catheter was inserted into the stomach. IPCO(2) was measured at rest and during bicycle exercise every 5 min. At rest arterial pCO(2) (aPCO(2)), intragastric pCO(2) (iPCO(2)) and the intragastric/arterial gap did not differ between patients and controls. During low level exercise (25 W), patients showed an increase in iPCO(2) compared to resting iPCO(2), whereas controls did not show an increase in iPCO(2) (change in iPCO(2): 12+/-2% vs. 1+/-0.4%, P<0.001). In CHF, iPCO(2) during peak exercise was 25+/-3% higher than at rest, compared to controls (increase 2+/-1, P<0.0001). CONCLUSIONS: Patients with CHF already at low level exercise develop an increase in iPCO(2). This is likely to reflect hypoperfusion of the intestinal mucosa, which may contribute to the development of bacterial translocation. |
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Authors:
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Andreas Krack; Barbara M Richartz; Anja Gastmann; Kasia Greim; Ulrich Lotze; Stefan D Anker; Hans R Figulla |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European journal of heart failure Volume: 6 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-06-08 Completed Date: 2004-11-08 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 403-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Friedrich-Schiller University, Erlanger Allee 101, D-07740, Jena, Germany. andreas.krack@med.uni-jena.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD14
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metabolism Biological Markers / analysis, blood Carbon Dioxide / metabolism* Chronic Disease Exercise / physiology* Exercise Test Female Germany Heart Failure / metabolism*, physiopathology* Humans Lactic Acid / metabolism Male Manometry Middle Aged Perfusion* Potassium / blood Prospective Studies Regression Analysis Rest / physiology* Sodium / blood Tumor Necrosis Factor-alpha / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD14; 0/Biological Markers; 0/Tumor Necrosis Factor-alpha; 124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid; 7440-09-7/Potassium; 7440-23-5/Sodium |
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