| Studies of intestinal lymphoid tissue. XV. Histopathologic features suggestive of cell-mediated reactivity in jejunal mucosae of patients with dermatitis herpetiformis. | |
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MedLine Citation:
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PMID: 2512740 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peroral jejunal mucosae from 32 patients with untreated DH were quantitated by computerized image-analysis in terms of surface (villous) and crypt epithelial volumes and their corresponding lymphoid infiltrates, together with lamina propria volumes, neutrophils, mast cells and basophils. Three distinctive patterns of mucosal abnormality were identified: (a) the "infiltrative" lesion in which normal villus epithelium was infiltrated by small, non-mitotic lymphocytes: (b) the "hyperplastic" type, in which crypt hyperplasia and hypertrophy together with lymphoid infiltration of crypt epithelium was additional to the "infiltrative" lesion, and in which lamina propria was swollen and contained modest neutrophilic and basophilic infiltration: and (c) the "destructive" lesion, identical to the classic celiac sprue appearances with effacement of villi, crypt hypertrophy and more intensive polymorph infiltration of lamina propria. These progressive lesions parallel those seen in experimental graft-versus-host reactions, so that the entire spectrum of changes described here in DH appear consistent with a cell-mediated mucosal response to gluten. The extent of mucosal abnormality was unrelated to individual HLA status. |
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Authors:
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M N Marsh |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Virchows Archiv. A, Pathological anatomy and histopathology Volume: 416 ISSN: 0174-7398 ISO Abbreviation: Virchows Arch A Pathol Anat Histopathol Publication Date: 1989 |
Date Detail:
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Created Date: 1990-01-19 Completed Date: 1990-01-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8302198 Medline TA: Virchows Arch A Pathol Anat Histopathol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 125-32 Citation Subset: IM |
Affiliation:
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University Department of Medicine, Hope Hospital (University of Manchester School of Medicine), England. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Biopsy Dermatitis Herpetiformis / immunology, pathology Female Glutens / immunology, pharmacology Humans Image Processing, Computer-Assisted Immunity, Cellular Intestinal Mucosa / immunology, pathology Intestines / immunology, pathology* Jejunum / immunology, pathology Lymphoid Tissue / immunology, pathology* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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8002-80-0/Glutens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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