| STUDIES IN TISSUE SPECIFICITY : II. THE ULTIMATE FATE OF MAMMALIAN TISSUE IMPLANTED IN THE CHICK EMBRYO. | |
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MedLine Citation:
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PMID: 19867756 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Rat tumors and other tissues of foreign species grow actively in the chick embryo until the onset of a refractory period. Grafts of rat sarcoma established and growing actively at the onset of this period show a rapid cessation of growth between the 18th and 19th days of incubation. This is followed by a widespread degeneration of the rat cells and a marked activity of the connective tissue elements in the embryonal tissue round about. An occasional specimen may show small mononuclear infiltration or rarely accumulations of polymorphonuclear cells in the neighborhood of the strange tissue. During the 20th and 21st days the connective tissue capsule increases rapidly, invading the graft and replacing it. The foreign cells disintegrate rapidly and by the 22d day have practically all disappeared. The period at which the established graft begins to degenerate, namely the 19th to the 20th day of incubation, is the one on which grafts of foreign tissue will no longer take when implanted in the embryo. The cells at the edge of the graft of foreign tissue survive for a time. There is a rapid formation of a connective tissue capsule and an invasion of the grafts. The foreign cells here practically all have disappeared by the 22d day, leaving a mass of connective tissue. The absence of a round cell infiltration is the most marked difference in the process in the embryo as compared with that in the adult chicken. The process about the grafts in newly hatched chicks is characterized by a more active response of the connective tissue than in the adult and a more pronounced round cell infiltration than in the embryo. |
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Authors:
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J B Murphy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of experimental medicine Volume: 19 ISSN: 0022-1007 ISO Abbreviation: J. Exp. Med. Publication Date: 1914 Feb |
Date Detail:
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Created Date: 2010-06-22 Completed Date: 2010-06-22 Revised Date: 2010-09-28 |
Medline Journal Info:
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Nlm Unique ID: 2985109R Medline TA: J Exp Med Country: United States |
Other Details:
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Languages: eng Pagination: 181-6 Citation Subset: - |
Affiliation:
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Laboratories of The Rockefeller Institute for Medical Research. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Exp Med ISSN: 0022-1007 ISSN: 1540-9538 Publisher: The Rockefeller University Press |
Article Information Download PDF  Copyright © Copyright, 1914, by The Rockefeller Institute for Medical Research New York Received Day: 15 Month: 12 Year: 1913 Print publication date: Day: 1 Month: 2 Year: 1914 Volume: 19 Issue: 2 First Page: 181 Last Page: 186 ID: 2125151 PubMed Id: 19867756 |
| STUDIES IN TISSUE SPECIFICITY : II. THE ULTIMATE FATE OF MAMMALIAN TISSUE IMPLANTED IN THE CHICK EMBRYO. | |
| James B. Murphy | |
| From the Laboratories of The Rockefeller Institute for Medical Research. |
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