Document Detail

Studies in neural tube defects. I. Epidemiologic and etiologic aspects.
MedLine Citation:
PMID:  3296753     Owner:  NLM     Status:  MEDLINE    
In the NIH Collaborative Perinatal Project, a prospective study of over 53,000 pregnant women and their offspring, 71 single-born children (13.33/10,000) were found to have a non-syndromal neural tube defect (NTD). A family history was present in only one case. The group of individuals with NTD was compared to a group of 400 randomly selected non-malformed control infants. Of over 50 maternal factors studied the following showed significant association with NTD in the offspring: diabetes mellitus; organic heart disease; lung disease; and diuretic, antihistamine, and sulfonamide use. The interval between the termination of the immediately previous pregnancy and the start of the proband pregnancy was significantly shorter in mothers of NTD children than in mothers of control infants. The risk for NTD was also significantly increased if the immediately previous pregnancy was a spontaneous abortion. There was no increased risk for NTDs among sibs of children with major malformations such as tracheo-esophageal "dysraphism," cleft lip/palate, or renal agenesis. NTDs are apparently etiologically heterogeneous.
N C Myrianthopoulos; M Melnick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of medical genetics     Volume:  26     ISSN:  0148-7299     ISO Abbreviation:  Am. J. Med. Genet.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-06-26     Completed Date:  1987-06-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7708900     Medline TA:  Am J Med Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  783-96     Citation Subset:  IM    
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MeSH Terms
Anencephaly / epidemiology
Encephalocele / epidemiology
Neural Tube Defects / epidemiology*,  etiology,  genetics
Sex Factors
Spina Bifida Occulta / epidemiology
United States

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