Document Detail

Studies in meconium: disaccharidase activities in meconium from cystic fibrosis patients and controls.
MedLine Citation:
PMID:  1196737     Owner:  NLM     Status:  MEDLINE    
Meconium ileus represents the earliest clinical manifestation of cystic fibrosis. The differences found in the composition and amount of protein, mucoprotein, mucopolysaccharides, and reducing sugars in meconium from newborns with cystic fibrosis might be of significance relative to the pathogenesis and early diagnosis of this disease. We studied the enzymatic activity of disaccharidases (lactase, sucrase, maltase, and palatinase) in meconium of infants with cystic fibrosis and controls. We found an increase in the specific activity of these enzymes in the meconium from infants with cystic fibrosis as compared to the specific activity in meconium from normal infants. The increase in the activities, expressed as micromols per gram of protein per minute was: lactase, 100 times higher; sucrase, 18 times; maltase, 4.8 times, and palatinase, 8.9 times.
I Antonowicz; S Ishida; H Shwachman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  56     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-02-09     Completed Date:  1976-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  782-7     Citation Subset:  AIM; IM    
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MeSH Terms
Cystic Fibrosis / diagnosis,  enzymology*
Disaccharidases / analysis*
Infant, Newborn
Meconium / enzymology*
Reg. No./Substance:
EC 3.2.1.-/Disaccharidases

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