| STUDIES IN EXPERIMENTAL SYPHILIS : IV. THE SURVIVAL OF TREPONEMA PALLIDUM IN THE INTERNAL ORGANS OF TREATED AND UNTREATED RABBITS. | |
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MedLine Citation:
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PMID: 19869032 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Simultaneous transfers to the testes of normal rabbits of circulating blood, heart muscle, liver, brain, spleen and bone marrow (mixed), inoculated testicle, and popliteal lymph nodes from a series of untreated syphilitic rabbits, demonstrated the persistence of the original infection unifomnly in the lymph nodes and less regularly in the liver, mixed spleen and bone marrow, and testis originally inoculated. In one instance the circulating blood was found to be infectious. Transfer of similar tissues from syphilitic rabbits treated with arsphenamine late in the course of the disease failed to disclose syphilitic infection of any of these tissues. In one animal, in which keratitis developed both before and after treatment, the blood, internal organs, and lymph nodes were found to be non-infectious in spite of the fact that the cornea was shown to be the site of a syphilitic inflammation. Transfer of lymph nodes or internal organs of treated syphilitic rabbits is probably the best method of evaluating an antisyphilitic agent, but it must be supplemented by careful observation of treated animals over an appreciable interval of time following treatment. The results of this study support the idea that failure to reinoculate a treated syphilitic animal does not necessarily mean the existence of the first infection but might beinterpreted as indicating the presence of an acquired resistance which persists in rabbits in which no trace of the first infection can be demonstrated. |
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Authors:
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A M Chesney; J E Kemp; |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of experimental medicine Volume: 42 ISSN: 0022-1007 ISO Abbreviation: J. Exp. Med. Publication Date: 1925 Jun |
Date Detail:
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Created Date: 2010-06-22 Completed Date: 2010-06-22 Revised Date: 2013-02-07 |
Medline Journal Info:
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Nlm Unique ID: 2985109R Medline TA: J Exp Med Country: United States |
Other Details:
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Languages: eng Pagination: 33-42 Citation Subset: - |
Affiliation:
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Department of Medicine of the Johns Hopkins Medical School, Baltimore. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Exp Med ISSN: 0022-1007 ISSN: 1540-9538 Publisher: The Rockefeller University Press |
Article Information Download PDF  Copyright © Copyright, 1925, by The Rockefeller Institute for Medical Research New York Received Day: 1 Month: 5 Year: 1925 Print publication date: Day: 30 Month: 6 Year: 1925 Volume: 42 Issue: 1 First Page: 33 Last Page: 42 ID: 2130988 PubMed Id: 19869032 |
| STUDIES IN EXPERIMENTAL SYPHILIS : IV. THE SURVIVAL OF TREPONEMA PALLIDUM IN THE INTERNAL ORGANS OF TREATED AND UNTREATED RABBITS. | |
| Alan M. Chesney | |
| Jarold E. Kemp | |
| With the Assistance of Allan K. Poole, M.D. | |
| From the Department of Medicine of the Johns Hopkins Medical School, Baltimore. |
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