Document Detail


Studies in fat grafting: Part II. Effects of injection mechanics on material properties of fat.
MedLine Citation:
PMID:  25028817     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although fat grafting can address many soft-tissue deficits, results remain inconsistent. In this study, the authors compared physical properties of fat following injection using an automated, low-shear device or the modified Coleman technique.
METHODS: Lipoaspirate was obtained from nine patients and processed for injection using either a modified Coleman technique or an automated, low-shear device. Fat was passed through a 2-mm cannula and compared with minimally processed fat. A rheometer was used to measure the storage modulus and shear rate at which tissues began to lose their solid-like properties. Viscosity was also measured, and gross properties of treatment groups were evaluated qualitatively with a glass slide test.
RESULTS: Fat injected through an automated, low-shear device closely matched physical properties of minimally processed fat. The storage modulus (G') of fat for the device group was greater than for the modified Coleman group, and the onset of breakdown was delayed. Similarly, viscosity measurement of fat from the automated device closely matched minimally processed fat and was greater than that of othe modified Coleman group.
CONCLUSIONS: The physical properties of lipoaspirate processed using an automated, low-shear device with a 2-mm cannula preserved the intactness of fat more than the modified Coleman technique. The authors' rheologic data demonstrate less damage using an automated device compared with the modified Coleman technique and potentially support its use for improved fat graft integrity.
Authors:
David Atashroo; Jordan Raphel; Michael T Chung; Kevin J Paik; Andreina Parisi-Amon; Adrian McArdle; Kshemendra Senarath-Yapa; Elizabeth R Zielins; Ruth Tevlin; Chris Duldulao; Graham G Walmsley; Michael S Hu; Arash Momeni; Brian Domecus; Joe R Rimsa; Lauren Greenberg; Geoffrey C Gurtner; Michael T Longaker; Derrick C Wan
Related Documents :
25028817 - Studies in fat grafting: part ii. effects of injection mechanics on material properties...
12371747 - N-3 fa increase liver uptake of hdl-cholesterol in mice.
12078997 - Effect of dietary fatty acids on the intestinal permeability of marker drug compounds i...
9368817 - Brown fat thermogenesis in rats fed high-fat diets enriched with n-3 polyunsaturated fa...
3105747 - Effect of protein restriction in insulin dependent diabetics at risk of nephropathy.
3293357 - Genetic factors in the regulation of adipose tissue distribution.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Plastic and reconstructive surgery     Volume:  134     ISSN:  1529-4242     ISO Abbreviation:  Plast. Reconstr. Surg.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-07-17     Completed Date:  2014-09-22     Revised Date:  2014-10-13    
Medline Journal Info:
Nlm Unique ID:  1306050     Medline TA:  Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-46     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / transplantation*
Biomechanical Phenomena
Humans
Injections / instrumentation,  methods*
Grant Support
ID/Acronym/Agency:
1R01 HL104236-01/HL/NHLBI NIH HHS; R01 AG-25016/AG/NIA NIH HHS; R01 DE021683/DE/NIDCR NIH HHS; R01 DE021683-01/DE/NIDCR NIH HHS; R01 DK-074095/DK/NIDDK NIH HHS; RC2 DE020771/DE/NIDCR NIH HHS; U01 HL099776/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Microvascular lifeboats: a stepwise approach to intraoperative venous congestion in DIEP flap breast...
Next Document:  Sterile inflammation after lymph node transfer improves lymphatic function and regeneration.