Document Detail

Studies on immunoreactive gastrin with special regard to its molecular form and G cell counts in gastrointestinal mucosa of fetal, neonatal and adult rats.
MedLine Citation:
PMID:  729996     Owner:  NLM     Status:  MEDLINE    
Changes of distribution of immunoreactive gastrin (IRG) and molecular forms of intra-tissue gastrin in the growth course of rats were examined. The results obtained were as follows; 1) IRG concentrations and G cell counts were extremely low in the fetal antral mucosa. However, a gradual increase of the above was observed during the neonatal suckling period, accompanied by a rapid increase at the commencement of feeding. 2) IRG concentrations in the duodenal mucosa of the fetal and neonatal period were markedly higher than that of adult rat. 3) Jejunal IRG concentration was negligible in the fetal period. The value obtained from the postnatal rats was equal to or higher than that of adult rat. 4) The major form of antral gastrin was G-17 throughout the fetal and adult age. No qualitative change of antral IRG in the growth course of rats was seen. 5) The major form of the duodeno-jejunal mucosa was G-17 in the fetal period and thereafter G-34 increased gradually in the growth course of rats. These results suggested that, (1) suckling and feeding appeared to be a trigger of the production and release of antral gastrin in the growth course of rats. (2) In the initial stage of the growth, G cells distributed in the duodeno-jejunal mucosa as well as in the antral mucosa may participated in the production and release mechanism of gastrin.
T Yabana; Y Kakumoto; K Watanabe; N Sekiyama; S Maeda; Y Narasaki; S Tsunoda; T Kondo; S Takasu; A Yachi; T Wada; K Sato
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastroenterologia Japonica     Volume:  13     ISSN:  0435-1339     ISO Abbreviation:  Gastroenterol. Jpn.     Publication Date:  1978  
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0152744     Medline TA:  Gastroenterol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  333-9     Citation Subset:  IM    
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MeSH Terms
Cell Count
Gastric Mucosa / analysis*,  cytology,  growth & development
Gastrins / analysis*
Intestinal Mucosa / analysis*,  cytology,  growth & development
Reg. No./Substance:

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