Document Detail


Studies on the immediate and delayed leucocytosis elicited by brief (30-min) strenuous exercise.
MedLine Citation:
PMID:  1618188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eight healthy male volunteers exercised for two 30-min sessions starting 3 h apart on an electronically braked cycle ergometer at a work load (mean 155.9 W, SD 33.4 W) which required an oxygen consumption that was 70% of their maximal rate of oxygen uptake. Venous blood samples were taken through an indwelling cannula over a period of 6 h beginning shortly before the first bout of exercise and were analysed for routine haematological parameters and for lactate, noradrenaline, adrenaline and cortisol. Both bouts of exercise induced an immediate leucocytosis due to rises in lymphocytes and neutrophils but only the first exercise bout induced a substantial delayed neutrophilia. In at least five subjects, changes in lymphocyte and platelet numbers were correlated (Spearman's rank procedure, P less than 0.05) with simultaneous changes in the plasma concentrations of lactate, noradrenaline and adrenaline over the 6-h period studied. Increases in the plasma concentration of cortisol due to exercise correlated positively with the percentage changes in neutrophil numbers at 3 h and 6 h. These results are consistent with the suggestion that the immediate and delayed leucocytosis induced by exercise are mediated respectively by catecholamine and by cortisol.
Authors:
D A McCarthy; I Macdonald; M Grant; M Marbut; M Watling; S Nicholson; J J Deeks; A J Wade; J D Perry
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  64     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1992  
Date Detail:
Created Date:  1992-08-06     Completed Date:  1992-08-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  513-7     Citation Subset:  IM    
Affiliation:
School of Biological Sciences, Queen Mary and Westfield College, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Volume / physiology
Catecholamines / blood
Exercise / physiology*
Humans
Hydrocortisone / blood
Leukocyte Count
Leukocytosis / physiopathology*
Male
Neutrophils / physiology
Oxygen Consumption / physiology
Platelet Count
Chemical
Reg. No./Substance:
0/Catecholamines; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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