| Studies on gynaecological hydrophilic lactic acid preparations. Part 5: The use of Eudragit E-100 as lactic acid carrier in intravaginal tablets. | |
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MedLine Citation:
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PMID: 12749409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intravaginal tablets based on hydrophilic methylcellulose and containing lactic acid complexed with Eudragit E-100 undergo deformation under standard conditions. The high flow--limit of gel originating from the tablets as well as its dynamic viscosity should enable durability of this dosage form on the vaginal mucosa. By selecting either 1 : 1 or 2 : 1 ratios of lactic acid to Eudragit E-100 it is possible to obtain tablets that disintegrate into a gelform at pH 3.8-4.4, i.e. the pH remains within the physiological range. Increasing the amount of lactic acid in the complex in relation to the polymer to a 4:1 ratio results in gels with a lower pH while possessing an acid reserve that can neutralize the excess of alkali present in severe vaginal infections. |
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Authors:
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K Małolepsza-Jarmołowska; A A Kubis; L Hirnle |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Die Pharmazie Volume: 58 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-05-16 Completed Date: 2003-07-02 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: Germany |
Other Details:
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Languages: eng Pagination: 260-2 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Technology, Faculty of Pharmacy, Wrocław Medical University, Wrocław, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intravaginal Chemistry, Physical Drug Carriers Excipients Gelatin Gels Hydrogen-Ion Concentration Lactic Acid / administration & dosage*, chemistry, pharmacokinetics Methacrylates Methylcellulose Physicochemical Phenomena Suppositories Viscosity |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Excipients; 0/Gels; 0/Methacrylates; 0/Suppositories; 24938-16-7/Eudragit-E; 50-21-5/Lactic Acid; 9000-70-8/Gelatin; 9004-67-5/Methylcellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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