Document Detail

Studies of a glomerular permeability factor in patients with minimal-change nephrotic syndrome.
MedLine Citation:
PMID:  2918948     Owner:  NLM     Status:  MEDLINE    
Peripheral blood mononuclear cells (PBMC) from patients with minimal-change nephrotic syndrome (MCNS) were tested for their ability to produce a factor which increases the urinary protein excretion levels of rats. It was shown that enhanced proteinuria can be produced in 8-hour urine specimens from rats by the injection of concentrated supernatants of cultured concanavalin-A-stimulated PBMC of patients with MCNS, but not from other nephrotics or normal subjects. The increase in urinary protein excretion was associated with a significant alteration of glomerular epithelial cells similar to that seen in MCNS. These results suggest that in MCNS, PBMC release a factor, which we termed a glomerular permeability factor (GPF), causing changes in glomerular permeability with resulting proteinuria.
N Yoshizawa; Y Kusumi; K Matsumoto; S Oshima; A Takeuchi; O Kawamura; T Kubota; S Kondo; H Niwa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephron     Volume:  51     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1989  
Date Detail:
Created Date:  1989-04-06     Completed Date:  1989-04-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  370-6     Citation Subset:  IM    
Second Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan.
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MeSH Terms
Concanavalin A / pharmacology
Kidney Glomerulus / metabolism*,  ultrastructure
Lymphocyte Activation
Middle Aged
Nephrosis, Lipoid / blood*
Proteinuria / etiology,  pathology
Rats, Inbred Strains
Reg. No./Substance:
11028-71-0/Concanavalin A

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