| Studies of a glomerular permeability factor in patients with minimal-change nephrotic syndrome. | |
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MedLine Citation:
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PMID: 2918948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peripheral blood mononuclear cells (PBMC) from patients with minimal-change nephrotic syndrome (MCNS) were tested for their ability to produce a factor which increases the urinary protein excretion levels of rats. It was shown that enhanced proteinuria can be produced in 8-hour urine specimens from rats by the injection of concentrated supernatants of cultured concanavalin-A-stimulated PBMC of patients with MCNS, but not from other nephrotics or normal subjects. The increase in urinary protein excretion was associated with a significant alteration of glomerular epithelial cells similar to that seen in MCNS. These results suggest that in MCNS, PBMC release a factor, which we termed a glomerular permeability factor (GPF), causing changes in glomerular permeability with resulting proteinuria. |
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Authors:
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N Yoshizawa; Y Kusumi; K Matsumoto; S Oshima; A Takeuchi; O Kawamura; T Kubota; S Kondo; H Niwa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nephron Volume: 51 ISSN: 0028-2766 ISO Abbreviation: Nephron Publication Date: 1989 |
Date Detail:
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Created Date: 1989-04-06 Completed Date: 1989-04-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0331777 Medline TA: Nephron Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 370-6 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Animals Concanavalin A / pharmacology Female Humans Kidney Glomerulus / metabolism*, ultrastructure Lymphocyte Activation Male Middle Aged Nephrosis, Lipoid / blood* Permeability Proteinuria / etiology, pathology Rats Rats, Inbred Strains Urine |
| Chemical | |
Reg. No./Substance:
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11028-71-0/Concanavalin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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