Document Detail

Studies of gastric emptying time in patients with non-ulcer dyspepsia.
MedLine Citation:
PMID:  17901768     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess the gastric emptying pattern of a standardized solid meal in patients with non-ulcer dyspepsia by using scintigraphic techniques. METHODS: Results for the half-emptying time for solids (T1/2) and percent clearance of solid meal at 60 min (C60) of patients (n=35) having non-ulcer dyspepsia according to Rome II criteria were compared with age- and sex-matched controls (n=28). Gastric emptying was studied by using egg omelette labelled with Tc tin colloid. Data acquisition was done using two protocols: dynamic acquisition was performed for the first 100 min and then static acquisition was carried out for up to 4 h. T1/2 and C60 were calculated from the computer-generated time-activity curve. RESULTS: The normal range of T1/2 was 29-88 min (mean+/-2 SD) among the control group. The mean T1/2 of the patient group was 160.1+/-96.1 min (P<0.01). Twelve of 22 male patients and 11 of 13 female patients had prolonged T1/2. The normal range of C60 was 92-28% (mean+/-2 SD) in the control group. The mean C60 of the patient group was 33.1+/-18.5% (P<0.01). Fifteen of 22 male patients and 11 of 13 female patients had shortened C60. CONCLUSION: Gastric emptying is significantly delayed in both men and women having non-ulcer dyspepsia as the T1/2 is prolonged and the C60 is shortened in a significant number of these patients. Radionuclide tests might offer an objective way of assessing this particular aspect of gastric physiology.
Muhammad Kashif Rahim; Durr-E-Sabih; Abdul Mateen; Najam-Uddin; Muhammad Yousaf
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  28     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-09-28     Completed Date:  2008-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  852-8     Citation Subset:  IM    
Department of Nuclear Medicine, Multan Institute of Nuclear Medicine and Radiotherapy, Pakistan.
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MeSH Terms
Dyspepsia / physiopathology*,  radionuclide imaging*
Gastric Emptying / physiology*
Middle Aged
Reference Values
Stomach / physiopathology*,  radionuclide imaging*

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