Document Detail

Studies of the functional significance of angiotensin II receptors in the rat olfactory bulb: evidence for alterations in normal fluid intake.
MedLine Citation:
PMID:  6286174     Owner:  NLM     Status:  MEDLINE    
The effects of continuous infusion of angiotensin II (ANG II, 1 microgram hr-1) into the olfactory bulb (O.B.) were studied on rats with chronically indwelling intracerebral cannulae. Chronic infusion (ALZA minipump system) of ANG II into the O.B. elicited a moderate dipsogenesis as compared to saline infused animals. The increased drinking occurred only during the dark phase (6 pm - 6 am) and appeared to be associated with food intake, which also occurred during this time. Removal of the food or disconnection of the minipump reduced water consumption to comparable levels in both groups. Acute injection of ANG II (250 ng) into the O.B. failed to elicit drinking. Since the olfactory bulb has a high concentration of ANG II receptors, these experiments suggest that ANG II may interact with the O.B. to facilitate the drinking associated with food intake.
F M Chen; D Healy; R Hawkins; M P Printz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and experimental hypertension. Part A, Theory and practice     Volume:  4     ISSN:  0730-0077     ISO Abbreviation:  Clin Exp Hypertens A     Publication Date:  1982  
Date Detail:
Created Date:  1982-10-21     Completed Date:  1982-10-21     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  8207790     Medline TA:  Clin Exp Hypertens A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  623-37     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / pharmacology*
Drinking Behavior / drug effects
Olfactory Bulb / physiology*
Rats, Inbred Strains
Receptors, Angiotensin / physiology*
Receptors, Cell Surface / physiology*
Grant Support
Reg. No./Substance:
0/Receptors, Angiotensin; 0/Receptors, Cell Surface; 11128-99-7/Angiotensin II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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