Document Detail

Studies of fluoride metabolism in man. A review and report of original data.
MedLine Citation:
PMID:  7010597     Owner:  NLM     Status:  MEDLINE    
The dietary intake of fluoride and the fluoride excretions in urine and stool were determined under controlled conditions in man. Fluoride balance studies have shown that the urinary fluoride corresponds to 50--60% of the intake, the fecal fluoride was very low, corresponding to 6% of the intake, and approximately 1 mg fluoride was retained per day during an average fluoride intake of 4.3 mg/day. The fluoride intake depended on the amount of fluoridated water consumed. The dietary fluoride content ranged from 1.2 to 1.5 mg/day. During the intake of supplemental fluoride the fluoride excretions increased but the ratio of the urinary/fecal fluoride was similar. Added fluoride is well retained. Following its discontinuation, very small amounts of the retained fluoride are excreted for several days. Inorganic elements, such as calcium, phosphorus, and magnesium, which have been shown to decrease the intestinal absorption of fluoride in animals were ineffective in man, while aluminum, given as aluminum-containing antacids, markedly decreased the intestinal absorption of fluoride and thereby decreased the retention of fluoride.
H Spencer; D Osis; M Lender
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The Science of the total environment     Volume:  17     ISSN:  0048-9697     ISO Abbreviation:  Sci. Total Environ.     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-05-26     Completed Date:  1981-05-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  1-12     Citation Subset:  IM    
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MeSH Terms
Aluminum / pharmacology
Body Burden
Calcium / pharmacology
Fluorides / metabolism*
Magnesium / pharmacology
Phosphorus / pharmacology
Water Supply
Grant Support
Reg. No./Substance:
0/Fluorides; 7429-90-5/Aluminum; 7439-95-4/Magnesium; 7440-70-2/Calcium; 7723-14-0/Phosphorus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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