Document Detail

Studies of fatty liver and kidney syndrome in chickens: dynamics of glucose metabolism.
MedLine Citation:
PMID:  588533     Owner:  NLM     Status:  MEDLINE    
1. Fatty liver and kidney syndrome (FLKS) was induced in a proportion of a group of 4-week-old chickens by giving a diet of meat meal and wheat; inclusion in the diet of animal tallow for 54 h substantially reduced the occurrence of FLKS. 2. Measurements of dynamic aspects of glucose metabolism were made with single injections of [2-3H]glucose which indicated that birds given the 'FLKS-inducing' diet and showing physical symptoms of FLKS had significantly lower rates of synthesis of glucose than birds given either the same diet supplemented with tallow or a commercial diet. 3. In a second series of experiments glucose metabolism was studied in birds (1) with or without physical symptoms that were given the 'FLKS-inducing' diet and (2) birds given the same diet supplemented with tallow or biotin. Affected birds fed the 'FLKS-inducing' diet had significantly lower plasma glucose concentrations, pool sizes and synthesis rates than birds fed the same diet and not showing symptoms, or birds fed the supplemented diets. 4. It is suggested that the cause of death in birds with FLKS is a low rate of gluconeogenesis during periods without feed which results in a lack of glucose to meet essential functions.
D Balnave; J Wolfenden; F M Ball; R B Cumming; R A Leng
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of nutrition     Volume:  38     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  1977 Nov 
Date Detail:
Created Date:  1978-02-23     Completed Date:  1978-02-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  329-34     Citation Subset:  IM    
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MeSH Terms
Chickens / metabolism*
Dietary Fats
Fatty Liver / metabolism,  veterinary*
Glucose / biosynthesis*
Kidney Diseases / metabolism,  veterinary*
Poultry Diseases / metabolism*
Reg. No./Substance:
0/Dietary Fats; 50-99-7/Glucose; 58-85-5/Biotin

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