Document Detail

Studies on the effects of monosodium glutamate (MSG) on oxidative stress in erythrocytes of adult male mice.
MedLine Citation:
PMID:  8600616     Owner:  NLM     Status:  MEDLINE    
Subcutaneous administration of monosodium glutamate (MSG) to normal adult male mice for 6 days at dose levels of 4 and 8 mg/g body weight caused a significant increase in erythrocyte glucose content accompanied by increased lipid peroxidation. The levels of total glutathione and protein-bound glutathione were significantly increased in the erythrocytes, whereas non-protein glutathione was significantly decreased. The administration of 4 and 8 mg/g body weight of MSG significantly increased the activities of glutathione reductase (GR), glutathione-S-transferase (GST) and glutathione peroxidase (GPX). It was observed that MSG, above 4 mg/g body weight, produced oxidative stress which was counteracted by the body by maintaining the level of glutathione, which was done by increasing the activity of its metabolizing enzymes.
P Ahluwalia; K Tewari; P Choudhary
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology letters     Volume:  84     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-05-02     Completed Date:  1996-05-02     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  161-5     Citation Subset:  IM    
Department of Biochemistry, Panjab University, Chandigarh, India.
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MeSH Terms
Ascorbic Acid / blood
Blood Glucose / metabolism
Blood Proteins / metabolism
Erythrocytes / drug effects*,  metabolism
Glutathione / blood
Glutathione Peroxidase / blood
Glutathione Reductase / blood
Glutathione Transferase / blood
Injections, Subcutaneous
Lipid Peroxidation / drug effects
Oxidative Stress / drug effects*
Sodium Glutamate / administration & dosage,  toxicity*
Reg. No./Substance:
0/Blood Glucose; 0/Blood Proteins; 142-47-2/Sodium Glutamate; 50-81-7/Ascorbic Acid; 70-18-8/Glutathione; EC Peroxidase; EC Reductase; EC Transferase

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